SMG1 and SMAD9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMG1	SMAD9
Gene Name		SMG1 phosphatidylinositol 3-kinase-related kinase	SMAD family member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding Metal Ion Binding Protein Dimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Response To Stress Gene Expression Peptidyl-serine Phosphorylation Protein Autophosphorylation Phosphatidylinositol Phosphorylation	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CDH5 PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A	117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		23049	4093
HPRD ID		06123	04484
Ensembl ID		ENSG00000157106	ENSG00000120693
Uniprot IDs		Q96Q15	O15198
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Transport RNA Transport RNA Localization Aromatic Compound Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Catabolic Process Nuclear Export Cytoplasmic Transport Intracellular Transport Catabolic Process RNA Metabolic Process Establishment Of Localization In Cell Gene Expression Cellular Localization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Junction Assembly Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Mullerian Duct Regression Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Histone MRNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Monopolar Cell Polarity Blood Vessel Maturation Regulation Of Translation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Translational Termination Dosage Compensation Golgi Vesicle Budding Positive Regulation Of Glial Cell Proliferation Anatomical Structure Regression Histone MRNA Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Posttranscriptional Regulation Of Gene Expression	Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process
Tagcloud ?		acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor
Tagcloud (Difference) ?		acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor
Tagcloud (Intersection) ?