SMG1 and UPF1

Number of citations of the paper that reports this interaction (PMID 11544179)
84

Data Source:
HPRD (in vivo)

		SMG1	UPF1
Gene Name		SMG1 phosphatidylinositol 3-kinase-related kinase	UPF1 regulator of nonsense transcripts homolog (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding Metal Ion Binding Protein Dimerization Activity	DNA Binding Chromatin Binding RNA Binding ATP-dependent RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Response To Stress Gene Expression Peptidyl-serine Phosphorylation Protein Autophosphorylation Phosphatidylinositol Phosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Gene Expression Histone MRNA Catabolic Process
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CDH5 PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A	31 interactors: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG GSPT2 HIRA LSM8 NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		23049	5976
HPRD ID		06123	03254
Ensembl ID		ENSG00000157106	ENSG00000005007
Uniprot IDs		Q96Q15	Q92900
PDB IDs			2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Transport RNA Transport RNA Localization Aromatic Compound Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Catabolic Process Nuclear Export Cytoplasmic Transport Intracellular Transport Catabolic Process RNA Metabolic Process Establishment Of Localization In Cell Gene Expression Cellular Localization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Junction Assembly Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Mullerian Duct Regression Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Histone MRNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Monopolar Cell Polarity Blood Vessel Maturation Regulation Of Translation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Translational Termination Dosage Compensation Golgi Vesicle Budding Positive Regulation Of Glial Cell Proliferation Anatomical Structure Regression Histone MRNA Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Posttranscriptional Regulation Of Gene Expression	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process RNA Localization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Surveillance MRNA Transport RNA Transport Gene Expression Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Nitrogen Compound Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Metabolic Process Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression Regulation Of Translation RRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Intracellular MRNA Localization RRNA Catabolic Process Positive Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Maturation Of 5.8S RRNA NcRNA Metabolic Process RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Formation Of Translation Preinitiation Complex RRNA Processing
Tagcloud ?		acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor	aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Difference) ?		acts aml antagonistically aza belongs decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none phosphoinositide readily restoring reversing suppressor	aav9 adeno als amyotrophic cord empty exerts forelimb green helps implicate mycupf1 nmd otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Intersection) ?		decay nonsense