SMG1 and UPF2

Number of citations of the paper that reports this interaction (PubMedID 11544179)
46

Data Source:
HPRD (in vivo)

		SMG1	UPF2
Description		SMG1 nonsense mediated mRNA decay associated PI3K related kinase	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Chromatoid Body	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus DNA Damage Response Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance Protein Autophosphorylation Phosphatidylinositol Phosphate Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Diverticular disease ( 30177863)
Interacting Genes		10 interacting genes: CDH5 PRKCI RNF10 SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		23049	26019
HPRD ID		06123	10405
Ensembl ID		ENSG00000157106	ENSG00000151461
Uniprot IDs		Q96Q15	Q9HAU5
PDB IDs		6L53 6L54 6SYT 6Z3R 7PW4 7PW5 7PW6 7PW7 7PW8 7PW9	1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Macromolecule Catabolic Process MRNA Transport RNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nucleobase-containing Compound Transport MRNA Export From Nucleus RNA Export From Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Catabolic Process Nuclear Export Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Glial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of RNA Splicing Nuclear Transport Nucleocytoplasmic Transport Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Late Endosome To Lysosome Transport Nucleic Acid Metabolic Process Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Biosynthetic Process Cellular Localization Intracellular Monoatomic Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Regulation Of Gliogenesis Double-stranded DNA Helicase Activity Supraspliceosomal Complex VCB Complex Regulation Of Telomere Maintenance Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Golgi Vesicle Budding	RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process
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