SMG1 and CDH5

Number of citations of the paper that reports this interaction (PMID 10428027)
234

Data Source:
HPRD (in vivo)

		SMG1	CDH5
Gene Name		SMG1 phosphatidylinositol 3-kinase-related kinase	cadherin 5, type 2 (vascular endothelium)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Cell-cell Junction Adherens Junction Tight Junction Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding Metal Ion Binding Protein Dimerization Activity	Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Ion Channel Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Response To Stress Gene Expression Peptidyl-serine Phosphorylation Protein Autophosphorylation Phosphatidylinositol Phosphorylation	Blood Vessel Maturation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Proliferation Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Cell Polarity
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CDH5 PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A	20 interactors: CSK CTNNA1 CTNNB1 CTNND1 DSP EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		23049	1003
HPRD ID		06123	03075
Ensembl ID		ENSG00000157106	ENSG00000179776
Uniprot IDs		Q96Q15	P33151
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Transport RNA Transport RNA Localization Aromatic Compound Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Catabolic Process Nuclear Export Cytoplasmic Transport Intracellular Transport Catabolic Process RNA Metabolic Process Establishment Of Localization In Cell Gene Expression Cellular Localization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Junction Assembly Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Mullerian Duct Regression Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Histone MRNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Monopolar Cell Polarity Blood Vessel Maturation Regulation Of Translation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Translational Termination Dosage Compensation Golgi Vesicle Budding Positive Regulation Of Glial Cell Proliferation Anatomical Structure Regression Histone MRNA Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Posttranscriptional Regulation Of Gene Expression	Cell-cell Junction Organization Adherens Junction Organization Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Indole-3-methanol Cell Junction Assembly Regulation Of ERK1 And ERK2 Cascade Cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Response To Stimulus Regulation Of Signal Transduction Response To Wounding Positive Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Cell Migration Cell Motility Wound Healing Response To Growth Factor Regulation Of Intracellular Signal Transduction Platelet Activation Organ Development Cellular Response To Organic Substance Cellular Component Assembly Cell Activation Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Organic Substance Movement Of Cell Or Subcellular Component Cell-cell Junction Assembly Protein Heterooligomerization Negative Regulation Of Signaling Regulation Of Protein Localization System Development Peptidyl-tyrosine Phosphorylation Response To Stress Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation
Tagcloud ?		acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor	1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?		acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor	1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?