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EPAS1 and SPP1
Number of citations of the paper that reports this interaction (PubMedID
22779921
)
0
Data Source:
BioGRID
(two hybrid)
EPAS1
SPP1
Description
endothelial PAS domain protein 1
secreted phosphoprotein 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Speck
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Vesicle
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cytokine Activity
Integrin Binding
Protein Binding
Small Molecule Binding
Extracellular Matrix Binding
Biological Process
Angiogenesis
Response To Hypoxia
Embryonic Placenta Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Epithelial Cell Maturation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Response To Oxidative Stress
Mitochondrion Organization
Signal Transduction
Visual Perception
Gene Expression
Hemopoiesis
Cell Differentiation
Erythrocyte Differentiation
Lung Development
Intracellular Oxygen Homeostasis
Norepinephrine Metabolic Process
MRNA Transcription By RNA Polymerase II
Surfactant Homeostasis
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Multicellular Organismal-level Iron Ion Homeostasis
Cellular Response To Hypoxia
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Protein Neddylation
Ossification
Osteoblast Differentiation
Androgen Catabolic Process
Cell Adhesion
Signal Transduction
Embryo Implantation
Cell Differentiation
Biomineral Tissue Development
Response To Vitamin D
Response To Macrophage Colony-stimulating Factor
Positive Regulation Of Bone Resorption
Positive Regulation Of DNA-templated Transcription
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Response To 2,3,7,8-tetrachlorodibenzodioxine
Positive Regulation Of Estradiol Secretion
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Transcriptional regulation of pluripotent stem cells
PTK6 Expression
Neddylation
Pexophagy
Regulation of PD-L1(CD274) transcription
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs
Vadadustat
Belzutifan
Diseases
Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
27680694
31043758
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Craniofacial microsomia (
26853712
)
Diisocyanate-induced asthma (
25918132
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Facial morphology (
29921221
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
30188897
)
High altitude adaptation (
28373541
)
Offspring birth weight (
31043758
)
Oxygenated hemoglobin levels (
30188897
)
P wave duration (
28794112
)
Peak velocity of the mitral A-wave (
28394258
)
PR interval (
32439900
)
Refractive error (
32231278
)
Renal cell carcinoma (
21131975
31231134
25826619
)
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Gout (
33832965
)
Urate levels (
31578528
)
Interacting Genes
41 interacting genes:
APC
ARNT
ARNT2
BATF
BATF2
BATF3
BBS1
BBS2
BBS4
BMAL1
BMAL2
CHD4
DBP
DDIT3
EGLN1
EGLN2
EGLN3
EIF3E
EP300
ESR1
ETV4
EWSR1
F12
JUN
KLHL20
KPNA1
KPNA3
KPNA5
KPNA6
KPNB1
MAX
MEF2C
NDN
PRKD1
SMAD3
SPP1
STAT5A
TERF2IP
UBE3B
USP20
VHL
97 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
CACNG4
CALM1
CC2D1B
CCR8
CD44
CEP162
CHD1
CIMIP5
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DRD2
DSEL
EEF1A1
EIF3K
EPAS1
ERBB2
F2
FTH1
GET3
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCS1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
PTGER4
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SGTB
SLC22A1
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
Entrez ID
2034
6696
HPRD ID
06787
01325
Ensembl ID
ENSG00000116016
ENSG00000118785
Uniprot IDs
B3KW07
Q99814
B7Z351
P10451
Q3LGB0
PDB IDs
1P97
2A24
3F1N
3F1O
3F1P
3H7W
3H82
4GHI
4GS9
4PKY
4XT2
5KIZ
5TBM
5UFP
6BVB
6CZW
6D09
6D0B
6D0C
6I7Q
6I7R
6X21
6X28
6X2H
6X37
6X3D
7Q5V
7Q5X
7UJV
8CK3
8CK4
8CK8
8Q5S
8Q64
8Q6D
8Q6E
8RUT
8RUV
8RUZ
8RV1
3CXD
3DSF
9EOU
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
DNA-binding Transcription Factor Activity
Positive Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
NLS-dependent Protein Nuclear Import Complex
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Nuclear Import Signal Receptor Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nuclear Localization Sequence Binding
Aryl Hydrocarbon Receptor Complex
NLS-bearing Protein Import Into Nucleus
Transcription Regulator Complex
DNA-binding Transcription Factor Binding
Peptidyl-proline 4-dioxygenase Activity
Integrated Stress Response Signaling
Cellular Response To Stress
Hypoxia-inducible Factor-proline Dioxygenase Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Localization To Organelle
Response To Stress
Response To Hypoxia
BBSome
Response To Decreased Oxygen Levels
Aryl Hydrocarbon Receptor Binding
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Response To Oxygen Levels
Cytoplasm
Cytosol
Modulation Of Chemical Synaptic Transmission
Wound Healing, Spreading Of Cells
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Integrin Complex
Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Biological Quality
Microtubule Associated Complex
Regulation Of Protein Metabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Lamellipodium Membrane
Regulation Of Proteolysis
Extracellular Exosome
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Negative Regulation Of Proteolysis
Negative Regulation Of Proteasomal Protein Catabolic Process
Integrin Alpha5-beta1 Complex
Cell Adhesion Mediated By Integrin
Integrin Alpha9-beta1 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta1 Complex
Ribosomal Subunit
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Focal Adhesion
Response To Stress
Endodermal Cell Differentiation
Developmental Process
Negative Regulation Of Protein Catabolic Process
Regulation Of System Process
Protein Kinase CK2 Complex
Alphav-beta3 Integrin-PKCalpha Complex
Dendritic Microtubule
Tail-anchored Membrane Protein Insertion Into ER Membrane
Monoatomic Cation Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Calcium Channel Regulator Activity
Metal Ion Transport
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Neddylation
Biological_process
Translation
Dendritic Spine
Cytosolic Ribosome
Ruffle Membrane
Cell-substrate Adhesion
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Tagcloud (Intersection)
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