EPAS1 and BBS1

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		EPAS1	BBS1
Gene Name		endothelial PAS domain protein 1	Bardet-Biedl syndrome 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex Cytosol	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Transcription From RNA Polymerase II Promoter Mitochondrion Organization Signal Transduction Visual Perception Erythrocyte Differentiation Lung Development Somatic Stem Cell Maintenance Norepinephrine Metabolic Process Surfactant Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Myoblast Fate Commitment Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Retina Homeostasis Organelle Organization Visual Perception Nonmotile Primary Cilium Assembly Cilium Assembly Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Protein Localization To Cilium
Pathways		Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Renal cell carcinoma ( 21131975)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		32 interactors: APC ARNT ARNT2 ARNTL ARNTL2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 EWSR1 F12 HSP90AA1 JUN KLHL20 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP VHL	13 interactors: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7
Entrez ID		2034	582
HPRD ID		06787	01950
Ensembl ID		ENSG00000116016	ENSG00000174483
Uniprot IDs		B3KW07 Q99814	E7EQH1 Q32MM9 Q8NFJ9
PDB IDs		1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Response To Stimulus Anatomical Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process System Development Developmental Process Nitrogen Compound Metabolic Process RNA Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Cellular Response To Oxygen Levels Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Leukocyte Activation Biosynthetic Process Leukocyte Differentiation Response To External Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Myeloid Leukocyte Differentiation	Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Interleukin-8 Production Response To Organic Substance Cellular Response To Oxidative Stress Cellular Response To Organic Substance Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Optic Chiasma Development Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Optic Nerve Formation Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Golgi To Plasma Membrane CFTR Protein Transport Glycolate Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Cellular Response To Glyoxal Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Dismutase Activity Cellular Protein Metabolic Process Regulation Of Heart Rate Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Peptidyl-cysteine Oxidation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Regulation Of Superoxide Dismutase Activity Positive Regulation Of Cellular Metabolic Process Response To Oxidative Stress Cellular Response To Reactive Oxygen Species
Tagcloud ?		2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a
Tagcloud (Difference) ?		2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a
Tagcloud (Intersection) ?