SPP1 and CISD2

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	CISD2
Gene Name		secreted phosphoprotein 1	CDGSH iron sulfur domain 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Protein Binding Protein Homodimerization Activity Poly(A) RNA Binding Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Mitochondrion Degradation Multicellular Organismal Aging Regulation Of Autophagy
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	2 interactors: APP SPP1
Entrez ID		6696	493856
HPRD ID		01325	17413
Ensembl ID		ENSG00000118785
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q8N5K1
PDB IDs		3CXD 3DSF	3FNV
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Negative Regulation Of Neuron Differentiation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cell Development Collateral Sprouting In Absence Of Injury Extracellular Matrix Organization Extracellular Structure Organization Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Regulation Of Neuron Differentiation Negative Regulation Of Axon Regeneration Chemotaxis Regulation Of Growth Neuron Remodeling Regulation Of Neurogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Bone Resorption Regulation Of Cell Development Regulation Of Axon Regeneration Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Reproduction Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Tissue Remodeling Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Decidualization Response To Vitamin D Cell Adhesion Mating Behavior Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Bone Resorption RNA Polyadenylation Neuron Recognition Reproductive Process Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Maternal Placenta Development Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Bone Remodeling Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	4q aging autophagic autophagy breakdown centenarian comparative created delay drives elucidated evolutionarily extension gives homeostasis interconnected knockout lifespan lived longevity mammals mapped organism pathophysiology premature shortened shortens siblings wolfram
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	4q aging autophagic autophagy breakdown centenarian comparative created delay drives elucidated evolutionarily extension gives homeostasis interconnected knockout lifespan lived longevity mammals mapped organism pathophysiology premature shortened shortens siblings wolfram
Tagcloud (Intersection) ?