SPP1 and PLD3

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	PLD3
Gene Name		secreted phosphoprotein 1	phospholipase D family, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Phospholipase D Activity Protein Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Phospholipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Lipid Catabolic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix	Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	6 interactors: ANXA7 BCL2L1 HGS NFKB1 SPP1 TK1
Entrez ID		6696	23646
HPRD ID		01325	07148
Ensembl ID		ENSG00000118785	ENSG00000105223
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q8IV08
PDB IDs		3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Response To Organic Cyclic Compound Response To Copper Ion Cellular Response To Alkaloid Response To Metal Ion Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Fetal Process Involved In Parturition Negative Regulation Of Interleukin-12 Biosynthetic Process Apoptotic Process In Bone Marrow Response To External Stimulus Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Skeletal Muscle Cell Proliferation Cell Proliferation Response To Alkaloid Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Lipid Membrane Organization Suppression By Virus Of Host Apoptotic Process Response To Hormone Negative Regulation Of Vitamin D Biosynthetic Process Response To Cortisol Thymidine Metabolic Process Positive Regulation Of MiRNA Metabolic Process Reproduction Negative Regulation Of Collateral Sprouting Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Response To Abiotic Stimulus Response To Stimulus Negative Regulation Of Axon Regeneration Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Execution Phase Of Apoptosis Cellular Response To Nicotine Single Organism Reproductive Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Cholesterol Transport Regulation Of MiRNA Metabolic Process Protein Targeting To Lysosome Reproductive Process Defense Response Negative Regulation Of Monooxygenase Activity Cellular Response To Virus
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	accumulated actually amyotrophic atrophy bioinformatics brains coexpressed confers doubled elevates exome granular granulin grn intense interacted modestly neuritic pgrn phospholipase plaques prgn progranulin pyramidal qpcr rs145999145 val232met wes
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	accumulated actually amyotrophic atrophy bioinformatics brains coexpressed confers doubled elevates exome granular granulin grn intense interacted modestly neuritic pgrn phospholipase plaques prgn progranulin pyramidal qpcr rs145999145 val232met wes
Tagcloud (Intersection) ?