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SPP1 and MMP7
Number of citations of the paper that reports this interaction (PubMedID
11375993
)
0
Data Source:
HPRD
(in vivo, in vitro)
SPP1
MMP7
Description
secreted phosphoprotein 1
matrix metallopeptidase 7
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Vesicle
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Extracellular Region
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Molecular Function
Cytokine Activity
Integrin Binding
Protein Binding
Small Molecule Binding
Extracellular Matrix Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Ossification
Osteoblast Differentiation
Androgen Catabolic Process
Cell Adhesion
Signal Transduction
Embryo Implantation
Cell Differentiation
Biomineral Tissue Development
Response To Vitamin D
Response To Macrophage Colony-stimulating Factor
Positive Regulation Of Bone Resorption
Positive Regulation Of DNA-templated Transcription
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Response To 2,3,7,8-tetrachlorodibenzodioxine
Positive Regulation Of Estradiol Secretion
Antibacterial Peptide Secretion
Antibacterial Peptide Biosynthetic Process
Proteolysis
Membrane Protein Ectodomain Proteolysis
Response To Xenobiotic Stimulus
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Membrane Protein Intracellular Domain Proteolysis
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Pathways
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Extra-nuclear estrogen signaling
Drugs
Marimastat
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases
GWAS
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Gout (
33832965
)
Urate levels (
31578528
)
Blood protein levels (
30072576
)
Night sleep phenotypes (
27126917
)
Prostate cancer (
23535732
)
Prostate-specific antigen levels (
28139693
)
Interacting Genes
97 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
CACNG4
CALM1
CC2D1B
CCR8
CD44
CEP162
CHD1
CIMIP5
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DRD2
DSEL
EEF1A1
EIF3K
EPAS1
ERBB2
F2
FTH1
GET3
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCS1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
PTGER4
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SGTB
SLC22A1
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
16 interacting genes:
BCAN
CD151
CD44
DCN
FASLG
HAPLN1
HBEGF
MBP
MMP1
MMP9
NGF
PLG
SERPINA1
SPP1
TFPI
TNFSF11
Entrez ID
6696
4316
HPRD ID
01325
01525
Ensembl ID
ENSG00000118785
ENSG00000137673
Uniprot IDs
B7Z351
P10451
Q3LGB0
P09237
PDB IDs
3CXD
3DSF
9EOU
1MMP
1MMQ
1MMR
2DDY
2MZE
2MZH
2MZI
2Y6C
2Y6D
5UE2
5UE5
7WXX
8JUD
8JUF
8JUG
8K4Z
Enriched GO Terms of Interacting Partners
?
Cytosol
Modulation Of Chemical Synaptic Transmission
Wound Healing, Spreading Of Cells
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Integrin Complex
Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Biological Quality
Microtubule Associated Complex
Regulation Of Protein Metabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Lamellipodium Membrane
Regulation Of Proteolysis
Extracellular Exosome
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Negative Regulation Of Proteolysis
Negative Regulation Of Proteasomal Protein Catabolic Process
Integrin Alpha5-beta1 Complex
Cell Adhesion Mediated By Integrin
Integrin Alpha9-beta1 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta1 Complex
Ribosomal Subunit
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Focal Adhesion
Response To Stress
Endodermal Cell Differentiation
Developmental Process
Negative Regulation Of Protein Catabolic Process
Regulation Of System Process
Protein Kinase CK2 Complex
Alphav-beta3 Integrin-PKCalpha Complex
Dendritic Microtubule
Tail-anchored Membrane Protein Insertion Into ER Membrane
Monoatomic Cation Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Calcium Channel Regulator Activity
Metal Ion Transport
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Neddylation
Biological_process
Translation
Dendritic Spine
Cytosolic Ribosome
Ruffle Membrane
Cell-substrate Adhesion
Extracellular Region
Extracellular Space
Extracellular Matrix
Cell Surface
Hyaluronic Acid Binding
Wound Healing, Spreading Of Cells
Extracellular Matrix Disassembly
Regulation Of Response To Wounding
Cellular Response To UV-A
Perineuronal Net
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Lipid Transport
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Positive Regulation Of Keratinocyte Migration
Response To UV-A
Positive Regulation Of Bone Resorption
Lysosomal Lumen
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Endopeptidase Activity
Regulation Of Cellular Component Organization
Cell Migration
Golgi Lumen
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Coagulation
Blood Coagulation
Protease Binding
Peptidase Inhibitor Activity
Hemostasis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Collateral Sprouting
System Development
Developmental Process
Cell Motility
Regulation Of Lipid Transport
Regulation Of Wound Healing
Positive Regulation Of Signal Transduction
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Tumor Necrosis Factor Receptor Binding
Central Nervous System Development
Extracellular Matrix Binding
Serine-type Endopeptidase Activity
Regulation Of Apoptotic Signaling Pathway
Signaling Receptor Binding
Positive Regulation Of ERBB Signaling Pathway
Regulation Of Bone Resorption
Collagen Catabolic Process
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Tagcloud (Intersection)
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