SPP1 and NACA

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		SPP1	NACA
Description		secreted phosphoprotein 1	nascent polypeptide associated complex subunit alpha
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Nascent Polypeptide-associated Complex Extracellular Exosome
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	DNA Binding Transcription Coactivator Activity Protein Binding Unfolded Protein Binding
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Ventricle Development Translation Protein Targeting To Membrane Negative Regulation Of Striated Muscle Cell Apoptotic Process Protein Transport Wound Healing Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Fiber Development Heart Trabecula Morphogenesis Negative Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Asthma ( 31619474) Atrial fibrillation ( 29892015 30061737) Diastolic blood pressure ( 30224653) JT interval ( 29874175) QRS duration ( 30012220)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	17 interacting genes: APLP1 CCDC90B FADD FOS FUNDC2 IGSF21 JUN LRIF1 MDM2 PPP1R18 PTEN SMYD1 SPP1 TBP TXLNA UCHL5 ZHX1
Entrez ID		6696	4666
HPRD ID		01325	03137
Ensembl ID		ENSG00000118785	ENSG00000196531
Uniprot IDs		B7Z351 P10451 Q3LGB0	E9PAV3 Q13765
PDB IDs		3CXD 3DSF 9EOU	3LKX 3MCB 3MCE 7QWQ 7QWR 7QWS 8P2K 9F1B 9F1C 9F1D 9FQ0
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Factor AP-1 Complex Receptor Serine/threonine Kinase Binding Forebrain Morphogenesis Response To Steroid Hormone Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of RNA Metabolic Process Synapse Maturation Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Response To Immobilization Stress Response To Muscle Stretch SMAD Protein Signal Transduction R-SMAD Binding Negative Regulation Of Neuron Projection Development Regulation Of Primary Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Proteolysis Alpha-2B Adrenergic Receptor Binding Developmental Process Response To Mechanical Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Medium-term Memory Integrated Stress Response Signaling Cellular Response To Prolactin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Response To Cocaine Negative Regulation Of Cell Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Proteolysis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Axonogenesis Cell Death Apoptotic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Animal Organ Development Programmed Cell Death
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