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SPP1 and ACP5
Number of citations of the paper that reports this interaction (PubMedID
2808373
)
0
Data Source:
HPRD
(in vitro)
SPP1
ACP5
Description
secreted phosphoprotein 1
acid phosphatase 5, tartrate resistant
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Vesicle
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Lysosome
Cytosol
Membrane
Molecular Function
Cytokine Activity
Integrin Binding
Protein Binding
Small Molecule Binding
Extracellular Matrix Binding
Acid Phosphatase Activity
Ferrous Iron Binding
Ferric Iron Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Ossification
Osteoblast Differentiation
Androgen Catabolic Process
Cell Adhesion
Signal Transduction
Embryo Implantation
Cell Differentiation
Biomineral Tissue Development
Response To Vitamin D
Response To Macrophage Colony-stimulating Factor
Positive Regulation Of Bone Resorption
Positive Regulation Of DNA-templated Transcription
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Response To 2,3,7,8-tetrachlorodibenzodioxine
Positive Regulation Of Estradiol Secretion
Nitric Oxide Biosynthetic Process
Negative Regulation Of Macrophage Cytokine Production
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Superoxide Anion Generation
Response To Cytokine
Superoxide Anion Generation
Negative Regulation Of Nitric Oxide Biosynthetic Process
Bone Resorption
Negative Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Bone Morphogenesis
Pathways
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Vitamin B2 (riboflavin) metabolism
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Gout (
33832965
)
Urate levels (
31578528
)
Blood protein levels (
30072576
)
Multiple sclerosis (severity) (
19010793
)
Interacting Genes
97 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
CACNG4
CALM1
CC2D1B
CCR8
CD44
CEP162
CHD1
CIMIP5
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DRD2
DSEL
EEF1A1
EIF3K
EPAS1
ERBB2
F2
FTH1
GET3
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCS1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
PTGER4
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SGTB
SLC22A1
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
12 interacting genes:
BCL2L13
EGR2
GPC4
MAPK9
PDCD5
PPP2CB
RPA2
SLC35F6
SNRNP40
SPP1
TNFSF10
ZBTB16
Entrez ID
6696
54
HPRD ID
01325
01374
Ensembl ID
ENSG00000118785
ENSG00000102575
Uniprot IDs
B7Z351
P10451
Q3LGB0
P13686
PDB IDs
3CXD
3DSF
9EOU
1WAR
2BQ8
Enriched GO Terms of Interacting Partners
?
Cytosol
Modulation Of Chemical Synaptic Transmission
Wound Healing, Spreading Of Cells
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Integrin Complex
Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Biological Quality
Microtubule Associated Complex
Regulation Of Protein Metabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Lamellipodium Membrane
Regulation Of Proteolysis
Extracellular Exosome
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Negative Regulation Of Proteolysis
Negative Regulation Of Proteasomal Protein Catabolic Process
Integrin Alpha5-beta1 Complex
Cell Adhesion Mediated By Integrin
Integrin Alpha9-beta1 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta1 Complex
Ribosomal Subunit
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Focal Adhesion
Response To Stress
Endodermal Cell Differentiation
Developmental Process
Negative Regulation Of Protein Catabolic Process
Regulation Of System Process
Protein Kinase CK2 Complex
Alphav-beta3 Integrin-PKCalpha Complex
Dendritic Microtubule
Tail-anchored Membrane Protein Insertion Into ER Membrane
Monoatomic Cation Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Calcium Channel Regulator Activity
Metal Ion Transport
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Neddylation
Biological_process
Translation
Dendritic Spine
Cytosolic Ribosome
Ruffle Membrane
Cell-substrate Adhesion
Rhombomere 5 Structural Organization
Rhombomere 3 Structural Organization
Rhombomere 3 Formation
Rhombomere 5 Formation
Mitochondrion Organization
Positive Regulation Of Programmed Cell Death
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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