SPP1 and RPL15

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	RPL15
Gene Name		secreted phosphoprotein 1	ribosomal protein L15
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytosol Ribosome Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	6 interactors: ARRB1 COPS6 IL7R MEOX2 SPP1 YWHAQ
Entrez ID		6696	6138
HPRD ID		01325	16043
Ensembl ID		ENSG00000118785	ENSG00000174748
Uniprot IDs		B7Z351 P10451 Q3LGB0	P61313
PDB IDs		3CXD 3DSF	3J3B
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Cell Size Interleukin-7-mediated Signaling Pathway Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of T Cell Mediated Cytotoxicity Somite Specification Cell Death Death Negative Regulation Of Collateral Sprouting Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Axon Regeneration Cullin Deneddylation Protein Deneddylation Regulation Of Cellular Component Size Organ Development G-protein Coupled Receptor Internalization Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Adhesion Negative Regulation Of Interleukin-8 Production Stress Fiber Assembly Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Bone Resorption Positive Regulation Of Organelle Organization Regulation Of Histone H4 Acetylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Segment Specification Regulation Of Axon Regeneration Positive Regulation Of Gene Expression Positive Regulation Of Receptor Internalization
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	aquaticus eubacteria identities intergenic l14 l18 l24 l30 l5 l6 maritima mesophile operon operons overlapped rpl14 rps14 rps17 rps8 s10 s14 s17 spacer spc thermophile thermophilus thermotoga thermus
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	aquaticus eubacteria identities intergenic l14 l18 l24 l30 l5 l6 maritima mesophile operon operons overlapped rpl14 rps14 rps17 rps8 s10 s14 s17 spacer spc thermophile thermophilus thermotoga thermus
Tagcloud (Intersection) ?