SPP1 and ITGA9

Number of citations of the paper that reports this interaction (PubMedID 10593924)
0

Data Source:
HPRD (in vitro, in vivo)

		SPP1	ITGA9
Description		secreted phosphoprotein 1	integrin subunit alpha 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integrin Complex Basal Plasma Membrane Cell Surface Membrane Integrin Alpha9-beta1 Complex
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	Protein Binding Signaling Receptor Activity Metal Ion Binding Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Neutrophil Chemotaxis Negative Regulation Of Vasoconstriction Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1
Drugs
Diseases			Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-human herpes virus 6 IE1A IgG seropositivity ( 33204752) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mortality in sepsis ( 27639821) Nasopharyngeal carcinoma ( 19478819) Phospholipid levels (plasma) ( 22359512) Platelet count ( 32888494) PR interval ( 23139255) Pulse pressure ( 30224653 30578418) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 30578418)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD
Entrez ID		6696	3680
HPRD ID		01325	04910
Ensembl ID		ENSG00000118785	ENSG00000144668
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q13797 Q8N6H6
PDB IDs		3CXD 3DSF 9EOU
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Angiogenesis Endothelial Cell Migration Regulation Of Collateral Sprouting Enzyme-linked Receptor Protein Signaling Pathway Myoblast Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Fibroblast Proliferation Protein Tyrosine Kinase Binding Axon Extension Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Growth Muscle Cell Differentiation Striated Muscle Cell Differentiation Response To Vitamin Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Neuron Projection Extension Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Transforming Growth Factor Beta Receptor Signaling Pathway Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Regulation Of Neurogenesis Regulation Of Nervous System Development Integrin Alpha9-beta1 Complex Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Neuron Apoptotic Process Regulation Of Cellular Component Organization Developmental Cell Growth Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Positive Regulation Of Neuron Maturation Diamine N-acetyltransferase Activity Regulation Of Estradiol Secretion Growth Factor Activity
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