SPP1 and PEPD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SPP1	PEPD
Description		secreted phosphoprotein 1	peptidase D
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Exosome
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Hydrolase Activity Dipeptidase Activity Manganese Ion Binding Metal Ion Binding Metalloaminopeptidase Activity Proline Dipeptidase Activity
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Proteolysis Amino Acid Metabolic Process Collagen Catabolic Process Negative Regulation Of Programmed Cell Death CARD8 Inflammasome Complex Assembly
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)	A body shape index ( 34021172) Adiponectin levels ( 22479202 24105470 31178129) Adult body size ( 32376654) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 27680694) Bitter alcoholic beverage consumption ( 31046077) Body fat percentage and HDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Creatine kinase levels ( 29403010) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) Fusiform gyrus volume ( 31530798) HDL cholesterol ( 30275531 24097068) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lead levels in blood ( 25820613) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 26198764) Systolic blood pressure ( 30224653) Triglyceride levels ( 28334899 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 22158537 28869590 32499647 30718926 30297969) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	4 interacting genes: ATXN1 SPP1 TERF1 USP7
Entrez ID		6696	5184
HPRD ID		01325	01358
Ensembl ID		ENSG00000118785	ENSG00000124299
Uniprot IDs		B7Z351 P10451 Q3LGB0	A0A140VJR2 P12955
PDB IDs		3CXD 3DSF 9EOU	2IW2 2OKN 5M4G 5M4J 5M4L 5M4Q 5MBY 5MBZ 5MC0 5MC1 5MC2 5MC3 5MC4 5MC5 6H2P 6H2Q 6QSB 6QSC 6SRE 6SRF 6SRG
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Estradiol Secretion Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Photoreceptor Cell Morphogenesis Adult Behavior Regulation Of Estradiol Secretion Symbiont-mediated Disruption Of Host Cell PML Body Hormone Metabolic Process Smoothened Binding POZ Domain Binding Androgen Catabolic Process BBSome Patched Binding Regulation Of Biological Quality Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Macrophage Colony-stimulating Factor Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Nuclear Telomere Cap Complex Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Regulation Of Chromosome Organization Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Monoubiquitinated Protein Deubiquitination Regulation Of Retrograde Transport, Endosome To Golgi Olfactory Behavior G-rich Strand Telomeric DNA Binding Nuclear Inclusion Body Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration T-circle Formation Telomeric Loop Disassembly Telomere Capping DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair
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