SPP1 and MARCKS

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		SPP1	MARCKS
Description		secreted phosphoprotein 1	myristoylated alanine rich protein kinase C substrate
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Actin Cytoskeleton Membrane Nuclear Speck Cell Junction Actin Filament Bundle Germinal Vesicle Organelle Extracellular Exosome
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	Actin Binding Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Apoptotic Process Mitochondrion Organization Actin Filament Organization Central Nervous System Development Neural Tube Development Neurogenesis Response To Endoplasmic Reticulum Stress Actin Filament Bundle Assembly Actin Crosslink Formation
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Acetylcholine regulates insulin secretion
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)	Alcohol dependence ( 33290381) Bipolar disorder (body mass index interaction) ( 24322204) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Household income ( 31844048) Household income (MTAG) ( 31844048) Type 2 diabetes ( 25760438)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	11 interacting genes: CALM2 CCNE1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB SPP1 TOB1
Entrez ID		6696	4082
HPRD ID		01325	07519
Ensembl ID		ENSG00000118785	ENSG00000277443
Uniprot IDs		B7Z351 P10451 Q3LGB0	P29966 Q6NVI1
PDB IDs		3CXD 3DSF 9EOU
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Kinase Activity Cyclin E1-CDK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphorylation Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Nuclear Membrane Disassembly Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Bone Resorption Nuclear Membrane Disassembly Membrane Disassembly Calyx Of Held Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Hormone Secretion Decidualization Nuclear Androgen Receptor Binding Presynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Regulation Of Mitotic Cell Cycle Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Hormone Levels Regulation Of Bone Resorption Regulation Of Cell Cycle Transferase Activity Response To Ketone Regulation Of Bone Remodeling Calcium Channel Regulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase C Binding Nuclear Membrane Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Chromatin Remodeling Cell Cycle G2/M Phase Transition Myristoyltransferase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
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