SPP1 and NCSTN

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		SPP1	NCSTN
Description		secreted phosphoprotein 1	nicastrin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Golgi Membrane Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Azurophil Granule Membrane Sarcolemma Melanosome Presynaptic Membrane Extracellular Exosome Gamma-secretase Complex Synaptic Membrane Secretory Vesicle
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	Endopeptidase Activity Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving ATPase Binding Endopeptidase Activator Activity Growth Factor Receptor Binding
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Learning Or Memory Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs
Diseases			Acne inversa; Hidradenitis supprativa
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	11 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN SPP1 TMED10
Entrez ID		6696	23385
HPRD ID		01325	05584
Ensembl ID		ENSG00000118785	ENSG00000162736
Uniprot IDs		B7Z351 P10451 Q3LGB0	A0A8V8TPQ8 A0A8V8TPR8 B4DR82 Q92542
PDB IDs		3CXD 3DSF 9EOU	2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8OQY 8OQZ 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Gamma-secretase Complex Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Notch Receptor Processing Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Protein Processing Protein Maturation Membrane Protein Intracellular Domain Proteolysis Synaptic Membrane Enzyme Binding Positive Regulation Of Proteolysis Endopeptidase Activator Activity Modulation Of Chemical Synaptic Transmission Golgi Apparatus Protein Metabolic Process Endoplasmic Reticulum Early Endosome Presynaptic Membrane Synaptic Vesicle Golgi Membrane Astrocyte Activation Involved In Immune Response Neuron Projection Organization Plasma Membrane Regulation Of Proteolysis Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Cellular Response To Amyloid-beta Negative Regulation Of Axonogenesis Aspartic Endopeptidase Activity, Intramembrane Cleaving Response To Amyloid-beta Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cytokine Production Cellular Response To Manganese Ion Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Learning Or Memory Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Transport Neuron Projection Maintenance Endoplasmic Reticulum Membrane Endosome Membrane Signal Transduction
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