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SPP1 and DSEL
Number of citations of the paper that reports this interaction (PubMedID
22779921
)
0
Data Source:
BioGRID
(two hybrid)
SPP1
DSEL
Description
secreted phosphoprotein 1
dermatan sulfate epimerase like
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Vesicle
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Golgi Membrane
Membrane
Molecular Function
Cytokine Activity
Integrin Binding
Protein Binding
Small Molecule Binding
Extracellular Matrix Binding
Sulfotransferase Activity
Isomerase Activity
Chondroitin-glucuronate 5-epimerase Activity
Biological Process
Ossification
Osteoblast Differentiation
Androgen Catabolic Process
Cell Adhesion
Signal Transduction
Embryo Implantation
Cell Differentiation
Biomineral Tissue Development
Response To Vitamin D
Response To Macrophage Colony-stimulating Factor
Positive Regulation Of Bone Resorption
Positive Regulation Of DNA-templated Transcription
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Response To 2,3,7,8-tetrachlorodibenzodioxine
Positive Regulation Of Estradiol Secretion
Dermatan Sulfate Proteoglycan Biosynthetic Process
Chondroitin Sulfate Proteoglycan Metabolic Process
Dermatan Sulfate Proteoglycan Metabolic Process
Pathways
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
DS-GAG biosynthesis
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Gout (
33832965
)
Urate levels (
31578528
)
Blood pressure (smoking interaction) (
25189868
)
Chronotype (
30696823
)
Cognitive performance (
19734545
)
Intraocular pressure (
29617998
)
Major depressive disorder (
20125088
)
Metabolite levels (
23823483
)
Night sleep phenotypes (
27126917
)
Non-response to selective serotonin reuptake inhibitors and depression (
27622933
)
Spatial memory (
31596458
)
Interacting Genes
97 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
CACNG4
CALM1
CC2D1B
CCR8
CD44
CEP162
CHD1
CIMIP5
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DRD2
DSEL
EEF1A1
EIF3K
EPAS1
ERBB2
F2
FTH1
GET3
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCS1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
PTGER4
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SGTB
SLC22A1
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
1 interacting genes:
SPP1
Entrez ID
6696
92126
HPRD ID
01325
10720
Ensembl ID
ENSG00000118785
ENSG00000171451
Uniprot IDs
B7Z351
P10451
Q3LGB0
Q8IZU8
PDB IDs
3CXD
3DSF
9EOU
Enriched GO Terms of Interacting Partners
?
Cytosol
Modulation Of Chemical Synaptic Transmission
Wound Healing, Spreading Of Cells
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Integrin Complex
Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Biological Quality
Microtubule Associated Complex
Regulation Of Protein Metabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Lamellipodium Membrane
Regulation Of Proteolysis
Extracellular Exosome
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Negative Regulation Of Proteolysis
Negative Regulation Of Proteasomal Protein Catabolic Process
Integrin Alpha5-beta1 Complex
Cell Adhesion Mediated By Integrin
Integrin Alpha9-beta1 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta1 Complex
Ribosomal Subunit
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Focal Adhesion
Response To Stress
Endodermal Cell Differentiation
Developmental Process
Negative Regulation Of Protein Catabolic Process
Regulation Of System Process
Protein Kinase CK2 Complex
Alphav-beta3 Integrin-PKCalpha Complex
Dendritic Microtubule
Tail-anchored Membrane Protein Insertion Into ER Membrane
Monoatomic Cation Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Calcium Channel Regulator Activity
Metal Ion Transport
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Neddylation
Biological_process
Translation
Dendritic Spine
Cytosolic Ribosome
Ruffle Membrane
Cell-substrate Adhesion
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Positive Regulation Of Estradiol Secretion
Regulation Of Estradiol Secretion
Positive Regulation Of Bone Resorption
Response To Macrophage Colony-stimulating Factor
Hormone Catabolic Process
Androgen Catabolic Process
Negative Regulation Of Collateral Sprouting
Negative Regulation Of Axon Regeneration
Cellular Response To Testosterone Stimulus
Negative Regulation Of Neuron Projection Regeneration
Response To 2,3,7,8-tetrachlorodibenzodioxine
Regulation Of Collateral Sprouting
Decidualization
Regulation Of Neuron Projection Regeneration
Response To Vitamin D
Extracellular Matrix Binding
Regulation Of Axon Regeneration
Small Molecule Binding
Androgen Metabolic Process
Steroid Catabolic Process
Regulation Of Bone Resorption
Embryo Implantation
Regulation Of Bone Remodeling
Response To Testosterone
Negative Regulation Of Axonogenesis
Response To Vitamin
Regulation Of Tissue Remodeling
Positive Regulation Of Lipid Transport
Negative Regulation Of Developmental Growth
Biomineral Tissue Development
Ossification
Osteoblast Differentiation
Negative Regulation Of Nervous System Development
Regulation Of Axonogenesis
Integrin Binding
Response To Nutrient
Regulation Of Lipid Transport
Negative Regulation Of Neurogenesis
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Hormone Secretion
Negative Regulation Of Cell Growth
Vesicle
Regulation Of Response To Wounding
Negative Regulation Of Cell Projection Organization
Hormone Metabolic Process
Cytokine Activity
Response To Ketone
Response To Steroid Hormone
Negative Regulation Of Growth
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