SPP1 and USP42

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		SPP1	USP42
Description		secreted phosphoprotein 1	ubiquitin specific peptidase 42
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Proteolysis Spermatogenesis Protein Deubiquitination Cell Differentiation Regulation Of Protein Stability Regulation Of Apoptotic Process
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Ub-specific processing proteases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	6 interacting genes: CPEB2 HRAS RNF10 SPP1 TP53 UBC
Entrez ID		6696	84132
HPRD ID		01325	18879
Ensembl ID		ENSG00000118785	ENSG00000106346
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q9H9J4
PDB IDs		3CXD 3DSF 9EOU
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis Negative Regulation Of Glial Cell Proliferation Cellular Response To Gamma Radiation Fibroblast Proliferation Negative Regulation Of Cell Development Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Response To Gamma Radiation Positive Regulation Of MiRNA Metabolic Process Cellular Response To Ionizing Radiation Cellular Senescence Ras Protein Signal Transduction Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Neurogenesis Regulation Of Tissue Remodeling Regulation Of Nervous System Development Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Cytoplasmic Translational Elongation Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Gliogenesis Phospholipase C Activator Activity Neuron Apoptotic Process Response To Ionizing Radiation GTPase Complex Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Cellular Response To Decreased Oxygen Levels Oxidative Stress-induced Premature Senescence Cellular Response To Hypoxia Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate MRNA 3'-UTR Binding Germ Cell Nucleus Cellular Response To Actinomycin D Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Population Proliferation Tissue Development Regulation Of Response To Wounding Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process
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