SPP1 and TMEM30A

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		SPP1	TMEM30A
Description		secreted phosphoprotein 1	transmembrane protein 30A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Phospholipid-translocating ATPase Complex
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding	Structural Molecule Activity Protein Binding Aminophospholipid Flippase Activity
	Biological Process	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion	Xenobiotic Transmembrane Transport Lipid Transport Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Protein Localization To Endosome Phospholipid Translocation Positive Regulation Of Phospholipid Translocation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Aminophospholipid Translocation
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	5 interacting genes: ACKR5 MAL OGT SPP1 TRIM54
Entrez ID		6696	55754
HPRD ID		01325	15535
Ensembl ID		ENSG00000118785	ENSG00000112697
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q9NV96
PDB IDs		3CXD 3DSF 9EOU	6K7G 6K7H 6K7I 6K7J 6K7K 6K7L 6K7M 6K7N 6LKN 7BSP 7BSQ 7BSS 7BSU 7BSV 7BSW 7PY4 7VGI 7VGJ 7VSG 7VSH 8OX4 8OX5 8OX6 8OX7 8OX8 8OX9 8OXA 8OXB 8OXC
Enriched GO Terms of Interacting Partners?		Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion	Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Membrane Raft Polarization Negative Regulation Of Cellular Component Organization Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Response To Nutrient Protein O-acetylglucosaminyltransferase Activity Protein Localization To Paranode Region Of Axon Membrane Raft Distribution Peptidase Activator Activity Involved In Apoptotic Process Androgen Catabolic Process Cellular Response To Testosterone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Membrane Raft Localization Response To 2,3,7,8-tetrachlorodibenzodioxine Protein Localization To Axon Lipid Binding Cellular Developmental Process Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Positive Regulation Of Bone Resorption Response To Macrophage Colony-stimulating Factor Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration NSL Complex Regulation Of Transcription By Glucose Hormone Catabolic Process Apical Protein Localization
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