SPP1 and CMTM3

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	CMTM3
Gene Name		secreted phosphoprotein 1	CKLF-like MARVEL transmembrane domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Cytokine Activity
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	9 interactors: APP BLNK BTK MAPK1 MEST MOB1A MOB3C RABAC1 SPP1
Entrez ID		6696	123920
HPRD ID		01325	16259
Ensembl ID		ENSG00000118785	ENSG00000140931
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q96MX0
PDB IDs		3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Defense Response Cell Activation B Cell Receptor Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Toll-like Receptor 4 Signaling Pathway Immune Response Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of B Cell Cytokine Production Toll-like Receptor Signaling Pathway Anatomical Structure Development Chemotaxis Regulation Of Cell Differentiation MAPK Import Into Nucleus Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Molecule Of Fungal Origin Synaptic Growth At Neuromuscular Junction Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Innate Immune Response Mesoderm Development Cell Maturation Tissue Development Collateral Sprouting In Absence Of Injury Developmental Process B Cell Activation Negative Regulation Of Cell Differentiation Cell Differentiation Response To External Stimulus Response To Stress Intracellular Signal Transduction Response To Molecule Of Fungal Origin Regulation Of Golgi Inheritance Positive Regulation Of Innate Immune Response Innate Immune Response Negative Regulation Of Neuron Differentiation Platelet Activation Placenta Development Caveolin-mediated Endocytosis Collateral Sprouting Axon Midline Choice Point Recognition Cytosine Metabolic Process Response To Lipid
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	arrest carcinomas cleavage colony core cpg downregulated downregulation frequently g2 inducing largely located methylation p21 parp partially putative re remain responsive silenced sp1 sp3 suppressed suppressor testicular testis tissues
Tagcloud (Difference) ?		able acquisition acts cbx7 chemokine contributing counteracts decreases encoding fact hmga1b interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	arrest cleavage colony core cpg downregulated downregulation frequently g2 largely located methylation p21 parp partially putative re remain responsive silenced sp1 sp3 suppressed suppressor testicular testis tissues
Tagcloud (Intersection) ?		carcinomas inducing