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EPAS1 and APC
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
36
Data Source:
BioGRID
(two hybrid)
EPAS1
APC
Description
endothelial PAS domain protein 1
APC regulator of Wnt signaling pathway
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Speck
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Leading Edge Membrane
Ruffle Membrane
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Plasma Membrane Bounded Cell Projection
Wnt Signalosome
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Angiogenesis
Response To Hypoxia
Embryonic Placenta Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Epithelial Cell Maturation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Response To Oxidative Stress
Mitochondrion Organization
Signal Transduction
Visual Perception
Gene Expression
Hemopoiesis
Cell Differentiation
Erythrocyte Differentiation
Lung Development
Intracellular Oxygen Homeostasis
Norepinephrine Metabolic Process
MRNA Transcription By RNA Polymerase II
Surfactant Homeostasis
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Multicellular Organismal-level Iron Ion Homeostasis
Cellular Response To Hypoxia
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Protein Neddylation
Mitotic Cytokinesis
Cell Fate Specification
Heart Valve Development
Endocardial Cushion Morphogenesis
DNA Damage Response
Negative Regulation Of Microtubule Depolymerization
Mitotic Spindle Assembly Checkpoint Signaling
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Wnt Signaling Pathway
Cell Migration
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Microtubule-based Movement
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Localization To Centrosome
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Transcriptional regulation of pluripotent stem cells
PTK6 Expression
Neddylation
Pexophagy
Regulation of PD-L1(CD274) transcription
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Drugs
Vadadustat
Belzutifan
Diseases
Congenital polycythemia; Familial erythrocytosis (ECYT)
Cancer of the anal canal
Familial adenomatous polyposis
Gastric cancer
Esophageal cancer
Gallbladder cancer
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
27680694
31043758
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Craniofacial microsomia (
26853712
)
Diisocyanate-induced asthma (
25918132
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Facial morphology (
29921221
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
30188897
)
High altitude adaptation (
28373541
)
Offspring birth weight (
31043758
)
Oxygenated hemoglobin levels (
30188897
)
P wave duration (
28794112
)
Peak velocity of the mitral A-wave (
28394258
)
PR interval (
32439900
)
Refractive error (
32231278
)
Renal cell carcinoma (
21131975
31231134
25826619
)
Age at first sexual intercourse (
34211149
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Appendicular lean mass (
33097823
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Daytime nap (
33568662
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
41 interacting genes:
APC
ARNT
ARNT2
BATF
BATF2
BATF3
BBS1
BBS2
BBS4
BMAL1
BMAL2
CHD4
DBP
DDIT3
EGLN1
EGLN2
EGLN3
EIF3E
EP300
ESR1
ETV4
EWSR1
F12
JUN
KLHL20
KPNA1
KPNA3
KPNA5
KPNA6
KPNB1
MAX
MEF2C
NDN
PRKD1
SMAD3
SPP1
STAT5A
TERF2IP
UBE3B
USP20
VHL
135 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
ATOSA
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG1
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PKNOX1
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
ZNF106
ZNF510
Entrez ID
2034
324
HPRD ID
06787
01439
Ensembl ID
ENSG00000116016
ENSG00000134982
Uniprot IDs
B3KW07
Q99814
P25054
R4GMU6
PDB IDs
1P97
2A24
3F1N
3F1O
3F1P
3H7W
3H82
4GHI
4GS9
4PKY
4XT2
5KIZ
5TBM
5UFP
6BVB
6CZW
6D09
6D0B
6D0C
6I7Q
6I7R
6X21
6X28
6X2H
6X37
6X3D
7Q5V
7Q5X
7UJV
8CK3
8CK4
8CK8
8Q5S
8Q64
8Q6D
8Q6E
8RUT
8RUV
8RUZ
8RV1
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
7F6M
7F7O
7XTY
8GSJ
8X2Q
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
DNA-binding Transcription Factor Activity
Positive Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
NLS-dependent Protein Nuclear Import Complex
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Nuclear Import Signal Receptor Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nuclear Localization Sequence Binding
Aryl Hydrocarbon Receptor Complex
NLS-bearing Protein Import Into Nucleus
Transcription Regulator Complex
DNA-binding Transcription Factor Binding
Peptidyl-proline 4-dioxygenase Activity
Integrated Stress Response Signaling
Cellular Response To Stress
Hypoxia-inducible Factor-proline Dioxygenase Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Localization To Organelle
Response To Stress
Response To Hypoxia
BBSome
Response To Decreased Oxygen Levels
Aryl Hydrocarbon Receptor Binding
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Response To Oxygen Levels
Cytoplasm
Organelle Organization
Structural Constituent Of Nuclear Pore
Cytoskeleton Organization
Supramolecular Fiber Organization
Cytosol
MRNA Transport
Nuclear Export
Nuclear Pore
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Beta-catenin Destruction Complex
Nuclear Transport
Nucleocytoplasmic Transport
RNA Transport
Nuclear Membrane
RNA Export From Nucleus
Cellular Localization
Cytoskeleton
Intracellular Protein Localization
Regulation Of Nucleocytoplasmic Transport
Intracellular Transport
Nucleobase-containing Compound Transport
Nuclear Localization Sequence Binding
Nuclear Envelope
Establishment Of Localization In Cell
Cadherin Binding
Regulation Of Protein Localization
Actin Filament Binding
Glutamatergic Synapse
Regulation Of Cellular Localization
Protein Export From Nucleus
Hemidesmosome
Intracellular Protein Transport
Actin Binding
Nucleus
Protein Transport
Cellular Component Assembly
Positive Regulation Of Nucleocytoplasmic Transport
Establishment Of Protein Localization
Cytoplasm
Regulation Of Cytoskeleton Organization
Canonical Wnt Signaling Pathway
Regulation Of Intracellular Transport
Structural Molecule Activity
Intermediate Filament Organization
Nuclear Pore Nuclear Basket
Regulation Of Intracellular Protein Transport
Nuclear Pore Organization
Microtubule
Regulation Of Centromeric Sister Chromatid Cohesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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