SPP1 and CSNK2A2

Number of citations of the paper that reports this interaction (PMID 8663267)
10

Data Source:
HPRD (in vitro)

		SPP1	CSNK2A2
Gene Name		secreted phosphoprotein 1	casein kinase 2, alpha prime polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytosol PcG Protein Complex
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		6696	1459
HPRD ID		01325	00279
Ensembl ID		ENSG00000118785	ENSG00000070770
Uniprot IDs		B7Z351 P10451 Q3LGB0	P19784
PDB IDs		3CXD 3DSF	3E3B 3OFM 3U87
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?		encoding