SPP1 and CHD1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	CHD1
Gene Name		secreted phosphoprotein 1	chromodomain helicase DNA binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Methylated Histone Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs			Epirubicin
Diseases
GWAS		Dental caries ( 23064961)	Renal sinus fat ( 22044751)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	9 interactors: BCLAF1 H3F3A HDAC1 HIST3H3 NCOR1 SAFB SPP1 SRSF3 SSRP1
Entrez ID		6696	1105
HPRD ID		01325	03668
Ensembl ID		ENSG00000118785	ENSG00000153922
Uniprot IDs		B7Z351 P10451 Q3LGB0	B3KT33 O14646
PDB IDs		3CXD 3DSF	2B2T 2B2U 2B2V 2B2W 2B2Y 4B4C
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Chromosome Organization Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Organelle Organization Negative Regulation Of Gene Expression, Epigenetic RNA Metabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Chromatin Modification Notch Signaling Pathway Regulation Of Growth Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Definitive Erythrocyte Differentiation Regulatory T Cell Differentiation Circadian Rhythm Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Chromatin Remodeling Regulation Of RNA Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Collateral Sprouting Regulation Of Gene Expression, Epigenetic
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	demand distinctly e5 e7 elongated engagement epiblast escs fail gastrulate globally grow highlighting intergenic normalized nucleoli output patterned pluripotent pol remodeler renewal ribosomal rnap sustain transcribed uncovered undergoes unusually
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	demand distinctly e5 e7 elongated engagement epiblast escs fail gastrulate globally grow highlighting intergenic normalized nucleoli output patterned pluripotent pol remodeler renewal ribosomal rnap sustain transcribed uncovered undergoes unusually
Tagcloud (Intersection) ?