EPAS1 and ARNT2

Number of citations of the paper that reports this interaction (PubMedID 23275444)
53

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		EPAS1	ARNT2
Description		endothelial PAS domain protein 1	aryl hydrocarbon receptor nuclear translocator 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Aryl Hydrocarbon Receptor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Epithelial Cell Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Oxidative Stress Mitochondrion Organization Signal Transduction Visual Perception Gene Expression Hemopoiesis Cell Differentiation Erythrocyte Differentiation Lung Development Intracellular Oxygen Homeostasis Norepinephrine Metabolic Process MRNA Transcription By RNA Polymerase II Surfactant Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Hypoxia Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Neddylation	Response To Hypoxia In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Response To Estradiol Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells PTK6 Expression Neddylation Pexophagy Regulation of PD-L1(CD274) transcription	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
Drugs		Vadadustat Belzutifan
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 30188897) High altitude adaptation ( 28373541) Offspring birth weight ( 31043758) Oxygenated hemoglobin levels ( 30188897) P wave duration ( 28794112) Peak velocity of the mitral A-wave ( 28394258) PR interval ( 32439900) Refractive error ( 32231278) Renal cell carcinoma ( 21131975 31231134 25826619)	Atrial fibrillation ( 29892015 30061737) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder ( 20351715) Body mass index ( 26426971) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		41 interacting genes: APC ARNT ARNT2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 BMAL1 BMAL2 CHD4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 ESR1 ETV4 EWSR1 F12 JUN KLHL20 KPNA1 KPNA3 KPNA5 KPNA6 KPNB1 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP UBE3B USP20 VHL	69 interacting genes: ADAMTSL4 AHR AP1M1 AP3M1 APP ARNT CALCOCO2 CAPN7 CCDC33 CDR2 CEP57L1 CEP63 CTBP1 DGCR6 DTX2 DYDC1 EPAS1 FAAP20 GOLGA2 HIF1A IKZF3 KIFC3 LMO2 LMO4 LZTS2 MAGEA4 MAGED1 MEIS2 MEOX2 MIPOL1 MTDH MTUS2 NCOA3 NDE1 NPAS2 NPAS4 OSGIN1 PDE4DIP PLSCR1 PSMB1 RBCK1 REL RFX6 RIMBP3 RINT1 SH3GL2 SIM1 SORBS3 SPAG5 SSBP3 SSX2IP STK16 SYCE1 TACC3 TADA2A TAX1BP3 TFIP11 TRAF1 TRAF2 TRIM23 TRIM27 TRIM37 TRIM42 TRIP6 TSPOAP1 USHBP1 USP7 VPS52 ZNF341
Entrez ID		2034	9915
HPRD ID		06787	06915
Ensembl ID		ENSG00000116016	ENSG00000172379
Uniprot IDs		B3KW07 Q99814	Q86TN1 Q9HBZ2 X5DQN9
PDB IDs		1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2 5KIZ 5TBM 5UFP 6BVB 6CZW 6D09 6D0B 6D0C 6I7Q 6I7R 6X21 6X28 6X2H 6X37 6X3D 7Q5V 7Q5X 7UJV 8CK3 8CK4 8CK8 8Q5S 8Q64 8Q6D 8Q6E 8RUT 8RUV 8RUZ 8RV1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Import Signal Receptor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Localization Sequence Binding Aryl Hydrocarbon Receptor Complex NLS-bearing Protein Import Into Nucleus Transcription Regulator Complex DNA-binding Transcription Factor Binding Peptidyl-proline 4-dioxygenase Activity Integrated Stress Response Signaling Cellular Response To Stress Hypoxia-inducible Factor-proline Dioxygenase Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding Protein Localization To Organelle Response To Stress Response To Hypoxia BBSome Response To Decreased Oxygen Levels Aryl Hydrocarbon Receptor Binding Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Response To Oxygen Levels Cytoplasm	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Protein Dimerization Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Nuclear Aryl Hydrocarbon Receptor Complex Nucleus Microtubule Organizing Center Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Centrosome Protein Heterodimerization Activity DNA-binding Transcription Factor Activity Chromatin Microtubule-based Process Positive Regulation Of Autophagy Regulation Of Primary Metabolic Process Establishment Of Localization In Cell Benzodiazepine Receptor Binding Positive Regulation Of Glycolytic Process Embryonic Placenta Development Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Intracellular Transport Regulation Of Gene Expression Tumor Necrosis Factor Receptor Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of ATP Metabolic Process Microtubule RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding
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