SPP1 and KCNIP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	KCNIP1
Gene Name		secreted phosphoprotein 1	Kv channel interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Dendrite Potassium Channel Complex Neuronal Cell Body
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Detection Of Calcium Ion Signal Transduction Synaptic Transmission Regulation Of Ion Transmembrane Transport Positive Regulation Of Action Potential Potassium Ion Transmembrane Transport
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Normalized brain volume ( 19010793)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	4 interactors: KCND1 KCND2 KCNIP2 SPP1
Entrez ID		6696	30820
HPRD ID		01325	06879
Ensembl ID		ENSG00000118785	ENSG00000182132
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q3YAD3 Q9NZI2
PDB IDs		3CXD 3DSF	1S1E 2I2R 2NZ0
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Monovalent Inorganic Cation Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Clustering Of Voltage-gated Potassium Channels Cation Transport Ion Transmembrane Transport Protein Homooligomerization Regulation Of Membrane Potential Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Transmembrane Transport Ion Transport Potassium Ion Export Neuronal Ion Channel Clustering Detection Of Calcium Ion Protein Oligomerization Membrane Repolarization Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Positive Regulation Of Tissue Remodeling Neuron Maturation Decidualization Response To Vitamin D Regulation Of Bone Resorption Maternal Placenta Development Regulation Of Bone Remodeling Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Protein Complex Assembly Negative Regulation Of Axonogenesis Regulation Of Tissue Remodeling Biomineral Tissue Development Regulation Of Cation Channel Activity Embryo Implantation Maternal Process Involved In Female Pregnancy Action Potential Negative Regulation Of Developmental Growth Extracellular Matrix Disassembly Negative Regulation Of Cell Morphogenesis Involved In Differentiation Leukocyte Chemotaxis Response To Vitamin
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	13th amphibian belongs ca2 calcium dorsal dre ectoderm ectodermal ef embryo engage entitled fate gastrulation neural neurogenesis plate presumptive progenitors repressor spatially symposium territories timely transients xenopus
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	13th amphibian belongs ca2 calcium dorsal dre ectoderm ectodermal ef embryo engage entitled fate gastrulation neural neurogenesis plate presumptive progenitors repressor spatially symposium territories timely transients xenopus
Tagcloud (Intersection) ?