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EPAS1 and PRKD1
Number of citations of the paper that reports this interaction (PubMedID
17024177
)
63
Data Source:
HPRD
(in vitro)
EPAS1
PRKD1
Description
endothelial PAS domain protein 1
protein kinase D1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Speck
Autophagosome Membrane
Nucleus
Cytoplasm
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Cell Cortex
Membrane
Z Disc
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Heat Shock Protein Binding
Identical Protein Binding
Metal Ion Binding
Protein Serine Kinase Activity
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Angiogenesis
Response To Hypoxia
Embryonic Placenta Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Epithelial Cell Maturation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Response To Oxidative Stress
Mitochondrion Organization
Signal Transduction
Visual Perception
Gene Expression
Hemopoiesis
Cell Differentiation
Erythrocyte Differentiation
Lung Development
Intracellular Oxygen Homeostasis
Norepinephrine Metabolic Process
MRNA Transcription By RNA Polymerase II
Surfactant Homeostasis
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Multicellular Organismal-level Iron Ion Homeostasis
Cellular Response To Hypoxia
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Protein Neddylation
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Immune System Process
Apoptotic Process
Inflammatory Response
Golgi Organization
Signal Transduction
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Nervous System Development
Positive Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril
Sphingolipid Biosynthetic Process
Cell Differentiation
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell-cell Adhesion Mediated By Cadherin
Innate Immune Response
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Cell Size
Negative Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Golgi Vesicle Transport
Defense Response To Gram-negative Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Sarcomere Organization
Transepithelial Transport
Cellular Response To Hydroperoxide
Response To Norepinephrine
Cellular Response To Norepinephrine Stimulus
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Cellular Response To Angiotensin
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Endothelin
Positive Regulation Of Endothelial Cell Chemotaxis
Regulation Of Integrin-mediated Signaling Pathway
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Transcriptional regulation of pluripotent stem cells
PTK6 Expression
Neddylation
Pexophagy
Regulation of PD-L1(CD274) transcription
Sphingolipid de novo biosynthesis
Drugs
Vadadustat
Belzutifan
Bryostatin 1
Fostamatinib
Diseases
Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
27680694
31043758
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Craniofacial microsomia (
26853712
)
Diisocyanate-induced asthma (
25918132
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Facial morphology (
29921221
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
30188897
)
High altitude adaptation (
28373541
)
Offspring birth weight (
31043758
)
Oxygenated hemoglobin levels (
30188897
)
P wave duration (
28794112
)
Peak velocity of the mitral A-wave (
28394258
)
PR interval (
32439900
)
Refractive error (
32231278
)
Renal cell carcinoma (
21131975
31231134
25826619
)
Academic attainment (English) (
33594131
)
Adult body size (
32376654
)
BMI (adjusted for smoking behaviour) (
28443625
)
Body mass index (
20935630
23669352
25673413
28552196
28448500
)
Body mass index (joint analysis main effects and physical activity interaction) (
28448500
)
Body mass index (joint analysis main effects and smoking interaction) (
28443625
)
Body mass index in physically active individuals (
28448500
)
Body size at age 10 (
32376654
)
California verbal learning test score (
31596458
)
Carotid plaque burden (
28282560
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Childhood body mass index (
26604143
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Daytime nap (
33568662
)
General cognitive ability (
29844566
)
General risk tolerance (MTAG) (
30643258
)
Hip circumference (
28552196
)
Household income (MTAG) (
31844048
)
IgM levels (
28628107
)
Intelligence (MTAG) (
29326435
)
Neurociticism (
29500382
)
Obesity-related traits (
23251661
)
Schizophrenia (
30285260
29483656
25056061
34099189
)
Spatial processing (
31596458
)
Systolic blood pressure (
30224653
)
Type 2 diabetes (
30130595
)
Urinary sodium excretion (
31409800
)
Waist circumference (
28552196
25673412
)
Weight (
28552196
)
Interacting Genes
41 interacting genes:
APC
ARNT
ARNT2
BATF
BATF2
BATF3
BBS1
BBS2
BBS4
BMAL1
BMAL2
CHD4
DBP
DDIT3
EGLN1
EGLN2
EGLN3
EIF3E
EP300
ESR1
ETV4
EWSR1
F12
JUN
KLHL20
KPNA1
KPNA3
KPNA5
KPNA6
KPNB1
MAX
MEF2C
NDN
PRKD1
SMAD3
SPP1
STAT5A
TERF2IP
UBE3B
USP20
VHL
33 interacting genes:
ABL1
ADAP1
AKAP13
BTK
C1QBP
COPS2
COPS5
COPS7A
EGFR
EPAS1
HDAC5
HDAC7
IBTK
IGF1R
JUN
KIDINS220
MAPK8
MAPK9
MT2A
NOS1
PLCG1
PLCG2
PPP1R14A
PRKCE
PRKCH
RACK1
SPRY2
SRC
SYK
TFAP2A
TP53
USP28
YWHAQ
Entrez ID
2034
5587
HPRD ID
06787
05668
Ensembl ID
ENSG00000116016
ENSG00000184304
Uniprot IDs
B3KW07
Q99814
F8WBA3
Q15139
PDB IDs
1P97
2A24
3F1N
3F1O
3F1P
3H7W
3H82
4GHI
4GS9
4PKY
4XT2
5KIZ
5TBM
5UFP
6BVB
6CZW
6D09
6D0B
6D0C
6I7Q
6I7R
6X21
6X28
6X2H
6X37
6X3D
7Q5V
7Q5X
7UJV
8CK3
8CK4
8CK8
8Q5S
8Q64
8Q6D
8Q6E
8RUT
8RUV
8RUZ
8RV1
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
DNA-binding Transcription Factor Activity
Positive Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
NLS-dependent Protein Nuclear Import Complex
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Nuclear Import Signal Receptor Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nuclear Localization Sequence Binding
Aryl Hydrocarbon Receptor Complex
NLS-bearing Protein Import Into Nucleus
Transcription Regulator Complex
DNA-binding Transcription Factor Binding
Peptidyl-proline 4-dioxygenase Activity
Integrated Stress Response Signaling
Cellular Response To Stress
Hypoxia-inducible Factor-proline Dioxygenase Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Localization To Organelle
Response To Stress
Response To Hypoxia
BBSome
Response To Decreased Oxygen Levels
Aryl Hydrocarbon Receptor Binding
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Response To Oxygen Levels
Cytoplasm
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Protein-containing Complex Assembly
Cytosol
Positive Regulation Of Cell Migration
Regulation Of Apoptotic Process
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Regulation Of Protein Modification Process
Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Enzyme Binding
Signal Transduction
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein-containing Complex
Negative Regulation Of Macromolecule Metabolic Process
Protein Phosphorylation
Regulation Of Post-translational Protein Modification
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Protein Kinase C Binding
Response To Lipid
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Process
Positive Regulation Of Epithelial Cell Migration
Protein Kinase Activity
Cell Activation
Regulation Of Protein Neddylation
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Cell Motility
Cellular Response To Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Immune Response-regulating Signaling Pathway
Regulation Of Locomotion
Positive Regulation Of Programmed Cell Death
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