EPAS1 and DDIT3

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		EPAS1	DDIT3
Description		endothelial PAS domain protein 1	DNA damage inducible transcript 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Late Endosome Cytosol Protein-DNA Complex CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex CHOP-ATF4 Complex CHOP-ATF3 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding CAMP Response Element Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Transcription Regulator Activator Activity
	Biological Process	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Epithelial Cell Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Oxidative Stress Mitochondrion Organization Signal Transduction Visual Perception Gene Expression Hemopoiesis Cell Differentiation Erythrocyte Differentiation Lung Development Intracellular Oxygen Homeostasis Norepinephrine Metabolic Process MRNA Transcription By RNA Polymerase II Surfactant Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Hypoxia Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Neddylation	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Maturation Diaphragm Contraction Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response ER Overload Response Response To Unfolded Protein Sensory Perception Of Sound Response To Wounding Anterior/posterior Axis Specification Gene Expression Regulation Of Autophagy Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-8 Production Response To Endoplasmic Reticulum Stress Response To Platelet-derived Growth Factor PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Response To Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Artery Development Response To Caloric Restriction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling HRI-mediated Signaling GDF15-GFRAL Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Vascular Associated Smooth Muscle Cell Migration Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells PTK6 Expression Neddylation Pexophagy Regulation of PD-L1(CD274) transcription	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Vadadustat Belzutifan
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)	Myxoid liposarcoma
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 30188897) High altitude adaptation ( 28373541) Offspring birth weight ( 31043758) Oxygenated hemoglobin levels ( 30188897) P wave duration ( 28794112) Peak velocity of the mitral A-wave ( 28394258) PR interval ( 32439900) Refractive error ( 32231278) Renal cell carcinoma ( 21131975 31231134 25826619)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		41 interacting genes: APC ARNT ARNT2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 BMAL1 BMAL2 CHD4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 ESR1 ETV4 EWSR1 F12 JUN KLHL20 KPNA1 KPNA3 KPNA5 KPNA6 KPNB1 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP UBE3B USP20 VHL	68 interacting genes: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 CDK6 CEBPB CEBPE CEBPG CRACR2A CREB3 CREB3L1 CREBL2 CSNK2A1 DBP DGCR2 DNMT3L DRC12 EMSY EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIMAP6 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JDP2 JUN JUNB JUND KPNA2 LMO2 LNX1 MAFF MAFG MAPK14 MCMBP NFE2L2 NFIL3 PCM1 PICALM POLR1D RAI1 RPS3 RPS3A SNAPC5 SPOP SRA1 SSX3 TEDC1 TNFSF12 TRIB3 TXN2 TXNDC2 VPS37C ZBTB25 ZC3H14 ZSCAN31
Entrez ID		2034	1649
HPRD ID		06787	00529
Ensembl ID		ENSG00000116016	ENSG00000175197
Uniprot IDs		B3KW07 Q99814	P35638 Q53YD1
PDB IDs		1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2 5KIZ 5TBM 5UFP 6BVB 6CZW 6D09 6D0B 6D0C 6I7Q 6I7R 6X21 6X28 6X2H 6X37 6X3D 7Q5V 7Q5X 7UJV 8CK3 8CK4 8CK8 8Q5S 8Q64 8Q6D 8Q6E 8RUT 8RUV 8RUZ 8RV1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Import Signal Receptor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Localization Sequence Binding Aryl Hydrocarbon Receptor Complex NLS-bearing Protein Import Into Nucleus Transcription Regulator Complex DNA-binding Transcription Factor Binding Peptidyl-proline 4-dioxygenase Activity Integrated Stress Response Signaling Cellular Response To Stress Hypoxia-inducible Factor-proline Dioxygenase Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding Protein Localization To Organelle Response To Stress Response To Hypoxia BBSome Response To Decreased Oxygen Levels Aryl Hydrocarbon Receptor Binding Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Response To Oxygen Levels Cytoplasm	RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Factor AP-1 Complex Nucleoplasm Cellular Response To Stress Regulation Of Metabolic Process Leukocyte Differentiation DNA-templated Transcription Nucleus Myeloid Cell Differentiation Mononuclear Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signaling Cassette Cell Differentiation Myeloid Leukocyte Differentiation Cellular Developmental Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding Cell Activation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
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