DCX and SPP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		DCX	SPP1
Gene Name		doublecortin	secreted phosphoprotein 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Neuron Projection	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Cytokine Activity Protein Binding Extracellular Matrix Binding
	Biological Process	Neuron Migration Nervous System Development Axon Guidance Central Nervous System Development Brain Development Central Nervous System Projection Neuron Axonogenesis Intracellular Signal Transduction Axon Extension Dendrite Morphogenesis	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Pathways		Axon guidance Neurofascin interactions L1CAM interactions	Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		29 interactors: ACD AP1M1 AP2M1 APP CALCOCO2 CDK5 FBXO25 GOLGA2 IKZF1 KIFC3 KRT40 KRTAP10-8 MEOX1 MID2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X ZBTB5	88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		1641	6696
HPRD ID		02127	01325
Ensembl ID		ENSG00000077279	ENSG00000118785
Uniprot IDs		A8K340 B4DM53 O43602	B7Z351 P10451 Q3LGB0
PDB IDs		1MJD 2BQQ 2XRP 4ATU	3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Cell Cycle Negative Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Regulation Of Organelle Organization Cell Division Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Biosynthetic Process Organelle Organization Regulation Of DNA Replication Regulation Of Developmental Growth Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of DNA Biosynthetic Process Movement Of Cell Or Subcellular Component Axonogenesis Cellular Component Assembly Protein Localization Positive Regulation Of Telomerase Activity Neuron Projection Development Cellular Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Regulation Of Growth Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Neuron Development Immune System Process Positive Regulation Of Telomere Maintenance Hippocampus Development Positive Regulation Of Organelle Organization Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Cell Morphogenesis Involved In Differentiation Forebrain Development Developmental Cell Growth Negative Regulation Of Viral Release From Host Cell Neuron Differentiation	Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process
Tagcloud ?		17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Difference) ?		17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Intersection) ?