DCX and SPAG5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DCX	SPAG5
Description		doublecortin	sperm associated antigen 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cell Projection Neuron Projection	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Midbody Centriolar Satellite Ciliary Rootlet Microtubule Plus-end Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Protein Binding Microtubule Binding
	Biological Process	Neuron Migration Nervous System Development Central Nervous System Development Cell Differentiation Axoneme Assembly Intracellular Signal Transduction Retina Development In Camera-type Eye	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Positive Regulation Of Intracellular Transport Establishment Of Spindle Orientation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Centrosome Regulation Of Metaphase Plate Congression Positive Regulation Of Spindle Assembly
Pathways		Neurofascin interactions
Drugs
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Interacting Genes		39 interacting genes: ACD AP1M1 AP2M1 APP BICD2 CALCOCO2 CDK5 FBXO25 FSD2 GOLGA2 HOOK2 IKZF1 KIFC3 KRT40 KRTAP10-8 MAPK9 MEOX1 MEOX2 MID2 MTUS2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RBM5 RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X VPS52 ZBTB10 ZBTB5 ZRANB1	59 interacting genes: AIRIM AMOTL2 ARNT2 ATN1 BARD1 CCDC33 CCHCR1 CDC20B CDK1 CENPH CHCHD3 DCLRE1B DCX EIF4E2 EIF4ENIF1 ENKD1 FBXO28 FMR1 GEM GOLGA8EP GOLGA8F HAUS1 IGFN1 IQCE KANSL1 KRT3 KRT75 LGALS14 LINGO1 MID1 MID2 NEBL NLGN3 ODF1 ORC6 PIMREG PKN1 PLK4 POLR2L POM121 RBM41 SH2D4A SHANK3 SMARCA2 SMARCE1 SNAP47 SNAPIN SPAG5-AS1 TSC1 TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZFYVE26 ZGPAT ZMAT2 ZNF385C ZNF572 ZNF688
Entrez ID		1641	10615
HPRD ID		02127	10246
Ensembl ID		ENSG00000077279	ENSG00000076382
Uniprot IDs		A0A1B0GWD1 A0A7P0T9C5 A0A804CF28 A8K340 O43602	Q96R06
PDB IDs		1MJD 2BQQ 2XRP 4ATU 5IKC 5IN7 5IO9 5IOI 5IP4 6FNZ 6REV 6RF2 6RF8 6RFD
Enriched GO Terms of Interacting Partners?		Shelterin Complex Microtubule Binding Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Intracellular Protein Localization Negative Regulation Of Telomere Maintenance Via Telomerase Intracellular Transport Establishment Of Localization In Cell Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Telomere Maintenance Cellular Localization Protein Transport Establishment Of Protein Localization Telomere Maintenance Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Component Organization Acetylcholine Receptor Activator Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Telomere Organization Cytoskeleton Growth Cone Organelle Organization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Vesicle-mediated Transport Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Regulation Of Organelle Organization Somite Specification Cell Division Regulation Of Establishment Of Protein Localization To Telomere Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Binding Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Supramolecular Fiber Organization Regulation Of Telomere Maintenance Chromosome Organization
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