DCX and PAFAH1B1

Number of citations of the paper that reports this interaction (PMID 11001923)
25

Data Source:
HPRD (in vitro, in vivo)

		DCX	PAFAH1B1
Gene Name		doublecortin	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Neuron Projection	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cell Cortex Axon Growth Cone Cell Leading Edge Motile Primary Cilium Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Protein Homodimerization Activity Phospholipase Binding Dynein Binding Dynein Intermediate Chain Binding Phosphoprotein Binding
	Biological Process	Neuron Migration Nervous System Development Axon Guidance Central Nervous System Development Brain Development Central Nervous System Projection Neuron Axonogenesis Intracellular Signal Transduction Axon Extension Dendrite Morphogenesis	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Organelle Organization Microtubule-based Process Mitotic Nuclear Division Nuclear Migration Synaptic Transmission Neuroblast Proliferation Learning Or Memory Retrograde Axon Cargo Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Regulation Of Rho GTPase Activity Osteoclast Development Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Nuclear Envelope Disassembly Establishment Of Centrosome Localization
Pathways		Axon guidance Neurofascin interactions L1CAM interactions	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ACD AP1M1 AP2M1 APP CALCOCO2 CDK5 FBXO25 GOLGA2 IKZF1 KIFC3 KRT40 KRTAP10-8 MEOX1 MID2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X ZBTB5	22 interactors: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DISC1 DNAI1 HSPH1 KARS KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		1641	5048
HPRD ID		02127	03329
Ensembl ID		ENSG00000077279	ENSG00000007168
Uniprot IDs		A8K340 B4DM53 O43602	P43034
PDB IDs		1MJD 2BQQ 2XRP 4ATU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Cell Cycle Negative Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Regulation Of Organelle Organization Cell Division Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Biosynthetic Process Organelle Organization Regulation Of DNA Replication Regulation Of Developmental Growth Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of DNA Biosynthetic Process Movement Of Cell Or Subcellular Component Axonogenesis Cellular Component Assembly Protein Localization Positive Regulation Of Telomerase Activity Neuron Projection Development Cellular Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Regulation Of Growth Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Neuron Development Immune System Process Positive Regulation Of Telomere Maintenance Hippocampus Development Positive Regulation Of Organelle Organization Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Cell Morphogenesis Involved In Differentiation Forebrain Development Developmental Cell Growth Negative Regulation Of Viral Release From Host Cell Neuron Differentiation	Microtubule-based Process Microtubule Cytoskeleton Organization Mitotic Cell Cycle Process Mitotic Nuclear Division Mitotic Cell Cycle Nervous System Development Neuron Migration Cell Cycle Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Regulation Of Neuron Projection Development Generation Of Neurons Organelle Localization Neurogenesis Microtubule Bundle Formation Cytoskeleton-dependent Intracellular Transport Cell Cycle Multicellular Organismal Development Regulation Of Cell Projection Organization System Development Establishment Of Organelle Localization Regulation Of Neuron Differentiation Organelle Organization Developmental Process Central Nervous System Development Anatomical Structure Development Regulation Of Neurogenesis Cellular Localization Brain Development G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cell Projection Organization Head Development Cell Migration Microtubule-based Movement Regulation Of Cell Development Dendrite Development Locomotion Establishment Of Chromosome Localization Cell Motility Cell Differentiation Cerebral Cortex Development Organelle Transport Along Microtubule Neuron Projection Extension Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Establishment Of Vesicle Localization Mitotic Centrosome Separation Microtubule Severing
Tagcloud ?		17p13 classical deletions disrupt epilepsy frontal gradient lis lis1 lissencephaly malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Difference) ?		17p13 classical deletions disrupt epilepsy frontal gradient lis malformation mutations occipital overlapping parietal proline q23 repeats retardation sequencing sexes southern splice sporadic though truncation wd40 xlis xq22	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Intersection) ?		lis1 lissencephaly