DCX and NFASC

Number of citations of the paper that reports this interaction (PubMedID 12223548)
44

Data Source:
HPRD (in vitro, in vivo)

		DCX	NFASC
Description		doublecortin	neurofascin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cell Projection Neuron Projection	Plasma Membrane Focal Adhesion Membrane Axon Paranodal Junction Node Of Ranvier Axon Initial Segment Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Neuron Migration Nervous System Development Central Nervous System Development Cell Differentiation Axoneme Assembly Intracellular Signal Transduction Retina Development In Camera-type Eye	Cell Adhesion Axon Guidance Brain Development Peripheral Nervous System Development Myelination Cell-cell Adhesion
Pathways		Neurofascin interactions	Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation
Drugs
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS			Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Clozapine-induced agranulocytosis ( 25187353) Dental caries ( 23064961) Diisocyanate-induced asthma ( 25918132) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) General risk tolerance (MTAG) ( 30643258) High myopia ( 32428537) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Regular attendance at a religious group ( 29970889)
Interacting Genes		39 interacting genes: ACD AP1M1 AP2M1 APP BICD2 CALCOCO2 CDK5 FBXO25 FSD2 GOLGA2 HOOK2 IKZF1 KIFC3 KRT40 KRTAP10-8 MAPK9 MEOX1 MEOX2 MID2 MTUS2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RBM5 RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X VPS52 ZBTB10 ZBTB5 ZRANB1	12 interacting genes: ABI1 ABI2 ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR
Entrez ID		1641	23114
HPRD ID		02127	12372
Ensembl ID		ENSG00000077279	ENSG00000163531
Uniprot IDs		A0A1B0GWD1 A0A7P0T9C5 A0A804CF28 A8K340 O43602	A0A7P0Z4R6 B4DRH7 O94856
PDB IDs		1MJD 2BQQ 2XRP 4ATU 5IKC 5IN7 5IO9 5IOI 5IP4 6FNZ 6REV 6RF2 6RF8 6RFD	3P3Y 3P40
Enriched GO Terms of Interacting Partners?		Shelterin Complex Microtubule Binding Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Intracellular Protein Localization Negative Regulation Of Telomere Maintenance Via Telomerase Intracellular Transport Establishment Of Localization In Cell Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Telomere Maintenance Cellular Localization Protein Transport Establishment Of Protein Localization Telomere Maintenance Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Component Organization Acetylcholine Receptor Activator Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Telomere Organization Cytoskeleton Growth Cone Organelle Organization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Vesicle-mediated Transport Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Regulation Of Organelle Organization Somite Specification Cell Division Regulation Of Establishment Of Protein Localization To Telomere Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Binding Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Supramolecular Fiber Organization Regulation Of Telomere Maintenance Chromosome Organization	Action Potential Propagation Neuronal Action Potential Propagation Cytoskeletal Anchor Activity Action Potential System Development Neuron Migration Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Sodium Channel Inhibitor Activity Sodium Channel Complex Actin-based Cell Projection Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Nervous System Development SCAR Complex Cell Projection Morphogenesis Voltage-gated Sodium Channel Complex Membrane Depolarization During Cardiac Muscle Cell Action Potential SH3 Domain Binding Filopodium Tip Neuron Projection Membrane Depolarization During Action Potential Sodium Ion Transmembrane Transport Transmembrane Transporter Binding Central Nervous System Development Regulation Of Neuron Projection Development Regulation Of Membrane Potential Cell Migration Nervous System Process Cell Junction Organization System Process Sodium Channel Regulator Activity Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuron Projection Development Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Cytoskeleton Organization Muscle Contraction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Neuron Projection Guidance Axon Guidance Cell Motility Cardiac Conduction Neuromuscular Process Controlling Balance Regulation Of Cellular Component Organization Regulation Of Membrane Depolarization Membrane Depolarization Synapse Organization
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