UBE2U and VPS11

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2U	VPS11
Gene Name		ubiquitin-conjugating enzyme E2U (putative)	vacuolar protein sorting 11 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Cytoplasm HULC Complex	Lysosome Lysosomal Membrane Endosome Late Endosome Endocytic Vesicle HOPS Complex Late Endosome Membrane
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding Zinc Ion Binding Syntaxin Binding
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Intracellular Protein Transport Vesicle-mediated Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2	25 interactors: BCAR1 BMI1 GGA3 KDM1A KIAA0368 KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45
Entrez ID		148581	55823
HPRD ID		14599	12258
Ensembl ID		ENSG00000177414	ENSG00000160695
Uniprot IDs		Q5VVX9	Q9H270
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction	Vesicle Organization Vesicle Fusion Vesicle-mediated Transport Organelle Fusion Vesicle Docking Protein Transport Membrane Docking Establishment Of Protein Localization Membrane Fusion Vesicle Docking Involved In Exocytosis Protein Localization Viral Life Cycle Regulation Of Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Cellular Component Organization Intracellular Transport Establishment Of Localization In Cell Viral Entry Into Host Cell Organelle Organization Entry Into Host Cell Membrane Organization Regulation Of SNARE Complex Assembly Cellular Protein Localization Viral Budding Cellular Localization Endosomal Transport Interaction With Host Viral Process Transport Protein Ubiquitination Virion Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Exocytosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Endosome Organization Histone Ubiquitination Protein Polyubiquitination Regulation Of Vesicle Fusion Regulation Of Protein Localization Protein Autoubiquitination Regulation Of Vacuole Fusion, Non-autophagic Ubiquitin-dependent Endocytosis Positive Regulation Of Receptor Localization To Synapse Regulation Of Primitive Erythrocyte Differentiation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process
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