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UBE2U and TRIM68
Number of citations of the paper that reports this interaction (PMID
19690564
)
33
Data Source:
BioGRID
(two hybrid)
UBE2U
TRIM68
Gene Name
ubiquitin-conjugating enzyme E2U (putative)
tripartite motif containing 68
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Cytoplasm
HULC Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
Histone Acetyltransferase Binding
Androgen Receptor Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cytokine-mediated Signaling Pathway
Protein Autoubiquitination
Interferon-gamma-mediated Signaling Pathway
Regulation Of Androgen Receptor Signaling Pathway
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Cytokine Signaling in Immune system
Drugs
Diseases
GWAS
Protein-Protein Interactions
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
2 interactors:
UBE2D3
UBE2U
Entrez ID
148581
55128
HPRD ID
14599
11507
Ensembl ID
ENSG00000177414
ENSG00000167333
Uniprot IDs
Q5VVX9
Q6AZZ1
PDB IDs
1YRV
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
Protein Polyubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
DNA Repair
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Macromolecule Catabolic Process
Protein K11-linked Ubiquitination
DNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Histone Ubiquitination
Protein K48-linked Ubiquitination
Protein Monoubiquitination
Negative Regulation Of Type I Interferon Production
Cellular Response To Stress
Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Catabolic Process
BMP Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Innate Immune Response
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Tagcloud
?
appearing
associate
compelling
defence
e3
fused
homologue
identifies
ifn
ligases
limits
lysosomal
monocytes
proteomic
regulator
rig
rlr
tank
tfg
tlr
tlr3
toll
traf
trim21
tripartite
trk
turning
turns
Tagcloud (Difference)
?
appearing
associate
compelling
defence
e3
fused
homologue
identifies
ifn
ligases
limits
lysosomal
monocytes
proteomic
regulator
rig
rlr
tank
tfg
tlr
tlr3
toll
traf
trim21
tripartite
trk
turning
turns
Tagcloud (Intersection)
?