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UBE2U and TRIM27
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
UBE2U
TRIM27
Gene Name
ubiquitin-conjugating enzyme E2U (putative)
tripartite motif containing 27
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Cytoplasm
HULC Complex
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Integral Component Of Plasma Membrane
Membrane
PML Body
Retromer Complex
Nuclear Membrane
Molecular Function
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Nucleic Acid Binding
DNA Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Metal Ion Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Adaptive Immune Response
Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Spermatogenesis
Cell Proliferation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Viral Transcription
Arp2/3 Complex-mediated Actin Nucleation
Retrograde Transport, Endosome To Golgi
Innate Immune Response
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Trimerization
Protein K63-linked Ubiquitination
Interferon-gamma Secretion
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Interleukin-2 Secretion
Negative Regulation Of Viral Release From Host Cell
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Platelet aggregation (
20526338
)
Protein-Protein Interactions
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
254 interactors:
ABCA1
ABCF3
AEN
AES
AMOTL2
ARHGEF3
ARHGEF5
ARIH2
ARMC7
ARNT2
ARPIN
ATPAF2
ATXN7
BABAM1
BAG1
BAG5
BEGAIN
BEX2
BMI1
BMP7
BYSL
C14orf105
C20orf195
CCDC102B
CCDC87
CCDC92
CCDC94
CCHCR1
CDC20B
CDC23
CDK18
CDKL3
CHCHD3
CHD4
CHUK
CKS1B
CLK2
CPNE2
CSRP2
CSRP2BP
CWF19L2
DCX
DDX6
DGCR6
DMRT3
DNMT1
DTNBP1
EHHADH
EID1
EIF3D
EIF3E
EIF4E
EIF4E2
EPC1
FAM103A1
FAM110A
FAM126B
FAM193B
FAM214A
FAM214B
FAM64A
FAM83A
FANCM
FARS2
FBF1
FBXL19
FBXW5
FHL3
FLJ38668
FOXB1
FOXC2
FXYD6
GATAD2B
GEM
GFAP
GFI1B
GFM2
GLYCTK
GNPDA2
GPANK1
GRB2
GTF2F1
HAUS1
HDAC1
HR
IKBKB
IKBKE
ILK
INPP5J
IQCE
IQUB
JOSD1
KANSL1
KAT5
KCTD15
KCTD9
KIAA1683
KIF1A
KIF9
KIFC3
LASP1
LENG1
LGALS14
LINC00526
LINGO1
LMO1
MAD2L2
MAGEA11
MAGED4B
MAGEF1
MAPKBP1
MAT2B
MBD4
MCM7
MCOLN1
MDM2
MED21
MEMO1
MIA3
MID2
MOS
MRPL40
MTMR6
MVP
NCK2
NDE1
NDEL1
NEBL
NEDD9
NEIL2
NEK6
NELFE
NME7
NOTCH2NL
NR1D2
NUDT21
OAS1
OTUB2
PIAS1
PIAS2
PIAS3
PIAS4
PLEKHN1
PML
POLE2
POLR1C
POLR3C
PPID
PPL
PPP1R18
PRAM1
PRKAA1
PRPF31
PSMA1
PSMB1
PSMB3
PTPMT1
PTPN23
PUS7L
RAB29
RB1
RBM23
RBM41
RBX1
RCOR3
RHPN1
RIBC1
RNF213
RNF25
SCNM1
SDCBP
SH2D4A
SIAH1
SIRPA
SLC15A3
SNRPA
SNRPB2
SORBS3
SPATA2
SPATC1L
SRSF2
STAMBPL1
STK16
STK25
TBC1D22B
TBK1
TCEA2
TCHP
TEAD4
TMSB4X
TMSB4XP6
TP53
TPM3
TPRKB
TRAF5
TRIM11
TRIM21
TRIM23
TRIM29
TRIM31
TRIM32
TRIM42
TRIM43
TRIM55
TRIM9
TSGA10IP
TSHZ3
TTLL10
TUBGCP4
TUFT1
TXNDC9
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2J1
UBE2K
UBE2L6
UBE2N
UBE2O
UBE2T
UBE2U
UBE2W
UBE2Z
UCHL3
UCHL5
UHRF2
USE1
USP2
USP7
UTP23
VPS25
VPS28
WDYHV1
WT1-AS
XPA
ZBTB16
ZC2HC1C
ZFC3H1
ZFYVE21
ZGPAT
ZMYND19
ZNF250
ZNF417
ZNF446
ZNF572
ZNF581
ZNF79
Entrez ID
148581
5987
HPRD ID
14599
15996
Ensembl ID
ENSG00000177414
ENSG00000204713
Uniprot IDs
Q5VVX9
P14373
PDB IDs
1YRV
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Cellular Metabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Protein K11-linked Ubiquitination
Negative Regulation Of Biosynthetic Process
Protein Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gene Expression
Cell Cycle
RNA Metabolic Process
Cellular Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cell Cycle Process
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Catabolic Process
Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Transcription, DNA-templated
Cellular Response To DNA Damage Stimulus
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Proteolysis
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Organelle Organization
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Metabolic Process
Tagcloud
?
bolstered
compacta
da
decreases
deficiency
degeneration
dopamine
dopaminergic
dramatically
exists
linkage
movement
mptp
neurodegenerative
neuron
neurotoxin
nigra
obvious
parkinson
pars
pc12
pd
promote
protects
rnai
shared
snpc
substantia
upregulated
Tagcloud (Difference)
?
bolstered
compacta
da
decreases
deficiency
degeneration
dopamine
dopaminergic
dramatically
exists
linkage
movement
mptp
neurodegenerative
neuron
neurotoxin
nigra
obvious
parkinson
pars
pc12
pd
promote
protects
rnai
shared
snpc
substantia
upregulated
Tagcloud (Intersection)
?