UBE2U and VPS41

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2U	VPS41
Gene Name		ubiquitin-conjugating enzyme E2U (putative)	vacuolar protein sorting 41 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Cytoplasm HULC Complex	Lysosomal Membrane Early Endosome Late Endosome Golgi-associated Vesicle Cytosol Microtubule Cytoskeleton Membrane HOPS Complex CORVET Complex
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Molecular_function Protein Binding Microtubule Binding Zinc Ion Binding GTPase Binding
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Targeting To Vacuole Biological_process Vesicle-mediated Transport Regulation Of SNARE Complex Assembly Vacuole Fusion, Non-autophagic Golgi Vesicle Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2	9 interactors: AKTIP AP3D1 APP HOOK1 HOOK2 HOOK3 MON1B UBE2U ZNF512B
Entrez ID		148581	27072
HPRD ID		14599	10402
Ensembl ID		ENSG00000177414	ENSG00000006715
Uniprot IDs		Q5VVX9	E9PF36 P49754
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction	Early Endosome To Late Endosome Transport Endosome To Lysosome Transport Endosome Organization Lysosomal Transport Lysosome Organization Endosomal Transport Vacuolar Transport Vacuole Organization Vesicle-mediated Transport Endomembrane System Organization Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Cellular Localization Protein Transport Establishment Of Protein Localization Axon Cargo Transport Organelle Organization Protein Localization Transport Synaptic Growth At Neuromuscular Junction Synaptic Vesicle Membrane Organization Microtubule-based Transport Collateral Sprouting In Absence Of Injury Cytoskeleton-dependent Intracellular Transport Regulation Of Protein Binding Eye Pigment Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Sequestering Of Zinc Ion Microtubule-based Process Axon Choice Point Recognition Eye Pigmentation Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Pigment Granule Maturation Endosome To Melanosome Transport Neuron Remodeling Cellular Pigment Accumulation Regulation Of Binding Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Neurogenesis Protein Localization To Centrosome Golgi Localization Microtubule-based Movement Negative Regulation Of Cell Development Cellular Copper Ion Homeostasis Interkinetic Nuclear Migration
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