UBE2U and TRIM34

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2U	TRIM34
Description		ubiquitin conjugating enzyme E2 U	tripartite motif containing 34
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GO Annotations	Cellular Component	HULC Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response Defense Response To Virus Regulation Of Primary Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	10 interacting genes: BIRC2 MKRN3 MNAT1 TRIM5 UBE2D2 UBE2K UBE2N UBE2U USP2 ZBP1
Entrez ID		148581	53840
HPRD ID		14599	16141
Ensembl ID		ENSG00000177414	ENSG00000258659
Uniprot IDs		A0A0A0MRP4 A0A140VJY9 Q5VVX9	Q9BYJ4
PDB IDs		1YRV	2EGP
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing	Protein Polyubiquitination Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Positive Regulation Of Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Regulation Of Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Regulation Of Protein Polyubiquitination Regulation Of Necroptotic Process Macromolecule Catabolic Process Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Left-handed Z-DNA Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Response To Cytokine Stimulus Protein K63-linked Ubiquitination Regulation Of Defense Response Nucleus Antiviral Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Modification Process Regulation Of Immune System Process FBXO Family Protein Binding Omegasome Positive Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Virus Ubiquitin Binding
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