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UBE2U and TRIM28
Number of citations of the paper that reports this interaction (PMID
19690564
)
33
Data Source:
BioGRID
(two hybrid)
UBE2U
TRIM28
Gene Name
ubiquitin-conjugating enzyme E2U (putative)
tripartite motif containing 28
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Cytoplasm
HULC Complex
Nucleus
Nucleoplasm
Nuclear Euchromatin
Nuclear Heterochromatin
RNA Polymerase II Transcription Factor Complex
Molecular Function
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Krueppel-associated Box Domain Binding
Sequence-specific DNA Binding
Poly(A) RNA Binding
Chromo Shadow Domain Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Epithelial To Mesenchymal Transition
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Embryo Implantation
Gene Expression
Protein Ubiquitination
Protein Sumoylation
Positive Regulation Of Transcription Factor Import Into Nucleus
DNA Methylation Involved In Embryo Development
Innate Immune Response
Positive Regulation Of DNA Repair
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Protein Oligomerization
Convergent Extension Involved In Axis Elongation
Embryonic Placenta Morphogenesis
Negative Regulation Of DNA Demethylation
Negative Regulation Of Viral Release From Host Cell
Regulation Of Genetic Imprinting
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
62 interactors:
CBX1
CBX3
CBX5
CDC34
CDCA4
CEBPB
CHAF1A
CHD3
ESR1
FES
HDAC10
HTRA2
IRF1
IRF7
LYN
MAGEA2
MAGEA2B
MAGEA3
MAGEA6
MAGED1
MYB
NDNL2
NR3C1
NR4A1
NR4A3
PFDN5
PPP4C
RNF4
SENP7
SERTAD1
SERTAD2
SETDB1
SIN3A
SKI
SMARCAD1
SPG7
STAT3
TRIM24
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
VHL
VIM
YWHAQ
ZNF10
ZNF133
ZNF140
ZNF197
ZNF354A
ZNF382
ZNF420
ZNF496
ZNF689
ZNF74
Entrez ID
148581
10155
HPRD ID
14599
03445
Ensembl ID
ENSG00000177414
ENSG00000130726
Uniprot IDs
Q5VVX9
Q13263
PDB IDs
1YRV
1FP0
2RO1
2YVR
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Protein K48-linked Ubiquitination
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Protein Polyubiquitination
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Catabolic Process
Cellular Metabolic Process
Regulation Of Cellular Process
Cellular Protein Catabolic Process
Positive Regulation Of Metabolic Process
Protein Ubiquitination
Biosynthetic Process
Protein Modification By Small Protein Conjugation
Protein K11-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Regulation Of Ubiquitin-protein Transferase Activity
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Tagcloud
?
accumulates
aging
becoming
damaged
depletion
genomes
il6
il8
ink4a
insults
kap1
knocked
krab
limits
mediating
mixture
ois
oncogene
partially
pathologies
prevented
profound
reinforcing
sasp
secrete
secretory
senescence
termed
undergo
Tagcloud (Difference)
?
accumulates
aging
becoming
damaged
depletion
genomes
il6
il8
ink4a
insults
kap1
knocked
krab
limits
mediating
mixture
ois
oncogene
partially
pathologies
prevented
profound
reinforcing
sasp
secrete
secretory
senescence
termed
undergo
Tagcloud (Intersection)
?