VPS11 and LSM1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		VPS11	LSM1
Description		VPS11 core subunit of CORVET and HOPS complexes	LSM1 homolog, mRNA degradation associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex	P-body Nucleus Cytoplasm Cytosol Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding MRNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process
Pathways		SARS-CoV-2 modulates autophagy	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 22037555 28991256 29483656)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45	32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11
Entrez ID		55823	27257
HPRD ID		12258	06281
Ensembl ID		ENSG00000160695	ENSG00000175324
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	A0A0S2Z590 O15116
PDB IDs
Enriched GO Terms of Interacting Partners?		Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process	Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex MRNA Catabolic Process MRNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Catabolic Process RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Catabolic Process RNA Splicing RNA Metabolic Process RNA Binding MRNA Processing Macromolecule Catabolic Process Spliceosomal Complex RNA Processing Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process U4 SnRNA 3'-end Processing Threonine-type Endopeptidase Activity Dystroglycan Binding Nucleolar Exosome (RNase Complex) Catabolic Process Proteasome Core Complex, Beta-subunit Complex Nuclear MRNA Surveillance U6 SnRNA Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Macromolecule Metabolic Process Precatalytic Spliceosome Catalytic Step 2 Spliceosome Proteasome Core Complex Nucleobase-containing Compound Metabolic Process RRNA Processing Ribonucleoprotein Complex SnRNA 3'-end Processing P-body RRNA Metabolic Process Positive Regulation Of Isotype Switching CTP Binding DATP Binding Protein Folding Chaperone Complex Plasma Membrane Raft Distribution Hydroxypyruvate Reductase [NAD(P)H] Activity
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