UBE2U and PCGF1

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2U	PCGF1
Description		ubiquitin conjugating enzyme E2 U	polycomb group ring finger 1
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GO Annotations	Cellular Component	HULC Complex	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)
Interacting Genes		69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	10 interacting genes: CALCOCO2 CBX7 FCHO1 H2AC4 MUC7 RNF125 RNF2 TRIM55 UBE2D3 UBE2U
Entrez ID		148581	84759
HPRD ID		14599	11404
Ensembl ID		ENSG00000177414	ENSG00000115289
Uniprot IDs		A0A0A0MRP4 A0A140VJY9 Q5VVX9	Q9BSM1
PDB IDs		1YRV	4HPL 4HPM 5JH5 8HCU
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing	Protein Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity PRC1 Complex Protein Modification By Small Protein Conjugation Post-translational Protein Modification PcG Protein Complex Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Granzyme B Production
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