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VPS11
Description
VPS11 core subunit of CORVET and HOPS complexes
Image
No pdb structure
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Endosome
Early Endosome
Late Endosome
Autophagosome
Endosome Membrane
Membrane
Clathrin-coated Vesicle
Endocytic Vesicle
HOPS Complex
Cytoplasmic Vesicle
Late Endosome Membrane
CORVET Complex
Vesicle Tethering Complex
Molecular Function
Nucleotide Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Syntaxin Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Intracellular Protein Transport
Vesicle Docking Involved In Exocytosis
Autophagy
Endosome Organization
Vacuole Organization
Endosome To Lysosome Transport
Protein Transport
Vesicle-mediated Transport
Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Endosomal Vesicle Fusion
Regulation Of SNARE Complex Assembly
Positive Regulation Of Protein Catabolic Process
Organelle Fusion
Regulation Of Organelle Assembly
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Body mass index (
29273807
)
Coronary artery disease (
29212778
33020668
)
HDL cholesterol levels (
32203549
)
Plateletcrit (
32888494
)
Novel Interacting Genes
5 novel interacting genes:
ALG9
FUT1
MALL
RNF26
WNT1
Interacting Genes
33 interacting genes:
BCAR1
BMI1
ECPAS
EZR
GGA3
GRSF1
KDM1A
KRTAP10-3
KRTAP10-8
LRSAM1
LSM1
MARK3
MON1B
MSN
RAB7A
RDX
RILP
RNF181
STX1A
STX6
STX7
STX8
TFAP2B
TRIM32
TSG101
UBE2D2
UBE2L3
UBE2U
UVRAG
VPS16
VPS18
VPS33A
VPS45
Entrez ID
55823
HPRD ID
12258
Ensembl ID
ENSG00000160695
Uniprot IDs
A0A087WXL6
B7Z879
Q9H270
PDB IDs
Enriched GO Terms of Interacting Partners
?
Late Endosome
Membrane Docking
Vesicle Organization
Organelle Membrane Fusion
Vesicle Fusion
Organelle Fusion
Endosome
Vesicle-mediated Transport
Intracellular Protein Transport
Membrane Fusion
Early Endosome
Vacuolar Transport
Endosome To Lysosome Transport
Intracellular Protein Localization
Lysosomal Transport
Positive Regulation Of Catabolic Process
Establishment Of Protein Localization
Protein Transport
Organelle Localization
Macromolecule Catabolic Process
Catabolic Process
Vesicle Docking
SNARE Binding
Regulation Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Cellular Localization
Chloride Channel Inhibitor Activity
CORVET Complex
Clathrin-coated Vesicle
Intracellular Transport
Organelle Localization By Membrane Tethering
Positive Regulation Of Early Endosome To Late Endosome Transport
Autophagosome
Membrane Organization
Endosome Organization
Late Endosome Membrane
Positive Regulation Of Protein Localization To Early Endosome
SNAP Receptor Activity
Endosomal Transport
Positive Regulation Of Protein Localization To Endosome
Establishment Of Localization In Cell
Endosome Membrane
SNARE Complex
HOPS Complex
Autophagy
Autophagosome Maturation
Syntaxin Binding
Regulation Of SNARE Complex Assembly
Endosomal Vesicle Fusion
Positive Regulation Of Protein Metabolic Process
Tagcloud
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