VPS11 and TSG101

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		VPS11	TSG101
Gene Name		vacuolar protein sorting 11 homolog (S. cerevisiae)	tumor susceptibility 101
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Late Endosome Endocytic Vesicle HOPS Complex Late Endosome Membrane	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Syntaxin Binding	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways			Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: BCAR1 BMI1 GGA3 KDM1A KIAA0368 KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45	69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		55823	7251
HPRD ID		12258	03229
Ensembl ID		ENSG00000160695	ENSG00000074319
Uniprot IDs		Q9H270	Q99816
PDB IDs			1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		Vesicle Organization Vesicle Fusion Vesicle-mediated Transport Organelle Fusion Vesicle Docking Protein Transport Membrane Docking Establishment Of Protein Localization Membrane Fusion Vesicle Docking Involved In Exocytosis Protein Localization Viral Life Cycle Regulation Of Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Cellular Component Organization Intracellular Transport Establishment Of Localization In Cell Viral Entry Into Host Cell Organelle Organization Entry Into Host Cell Membrane Organization Regulation Of SNARE Complex Assembly Cellular Protein Localization Viral Budding Cellular Localization Endosomal Transport Interaction With Host Viral Process Transport Protein Ubiquitination Virion Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Exocytosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Endosome Organization Histone Ubiquitination Protein Polyubiquitination Regulation Of Vesicle Fusion Regulation Of Protein Localization Protein Autoubiquitination Regulation Of Vacuole Fusion, Non-autophagic Ubiquitin-dependent Endocytosis Positive Regulation Of Receptor Localization To Synapse Regulation Of Primitive Erythrocyte Differentiation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process	Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator
Tagcloud ?			000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?			000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?