VPS11 and GRSF1

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		VPS11	GRSF1
Description		VPS11 core subunit of CORVET and HOPS complexes	G-rich RNA sequence binding factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing
Pathways		SARS-CoV-2 modulates autophagy	Viral mRNA Translation Mitochondrial RNA degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)	Type 2 diabetes ( 30718926)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45	55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3
Entrez ID		55823	2926
HPRD ID		12258	07276
Ensembl ID		ENSG00000160695	ENSG00000132463
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	Q12849
PDB IDs			2LMI 4QU6 4QU7
Enriched GO Terms of Interacting Partners?		Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development
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