UBE2U and TRIM2

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2U	TRIM2
Description		ubiquitin conjugating enzyme E2 U	tripartite motif containing 2
Image
GO Annotations	Cellular Component	HULC Complex	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Apolipoprotein A1 levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis ( 21654844) Thyrotoxic periodic paralysis ( 33105104)
Interacting Genes		69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	31 interacting genes: BCL2L11 CDK20 CIB3 COG3 CSNK1E DTNBP1 GJB5 KCTD7 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2C UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2H UBE2K UBE2N UBE2U UBE2W
Entrez ID		148581	23321
HPRD ID		14599	10279
Ensembl ID		ENSG00000177414	ENSG00000109654
Uniprot IDs		A0A0A0MRP4 A0A140VJY9 Q5VVX9	A0A0J9YW02 A0A6Q8PF74 A0A6Q8PG16 A0A6Q8PGG4 A0A6Q8PHP4 Q9C040
PDB IDs		1YRV	7B2R 7B96 7QRV 7ZJ3 8A38 8AMS
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination ATP Binding Transferase Activity Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein Catabolic Process ISG15 Transferase Activity Ubiquitin Ligase Complex ISG15-protein Conjugation Cellular Response To Stress DNA Damage Response Free Ubiquitin Chain Polymerization Catabolic Process Cytosol Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway DNA Repair Filopodium Tip Protein Binding Ubiquitin Binding Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein K6-linked Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Homeostasis DNA Metabolic Process Nucleus Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Defense Response To Virus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?