UBE2U and RNF150

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2U	RNF150
Description		ubiquitin conjugating enzyme E2 U	ring finger protein 150
Image			No pdb structure
GO Annotations	Cellular Component	HULC Complex	Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hip index ( 34021172) Malaria ( 31844061) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278)
Interacting Genes		69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	12 interacting genes: C3orf52 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2L3 UBE2L6 UBE2U UBE2W UBE2Z
Entrez ID		148581	57484
HPRD ID		14599	15258
Ensembl ID		ENSG00000177414	ENSG00000170153
Uniprot IDs		A0A0A0MRP4 A0A140VJY9 Q5VVX9	D6RIE5 Q9ULK6
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity Proteolysis ATP Binding Nucleotide Binding Catabolic Process Protein Metabolic Process Protein Monoubiquitination Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity ISG15-protein Conjugation Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Nucleoplasm Positive Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Protein Targeting To Mitochondrion Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Nucleus TOR Signaling Ubiquitin Protein Ligase Activity Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus HULC Complex Positive Regulation Of Post-translational Protein Modification Regulation Of TOR Signaling DNA Repair
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