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UBE2U and MKRN3
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
UBE2U
MKRN3
Gene Name
ubiquitin-conjugating enzyme E2U (putative)
makorin ring finger protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Cytoplasm
HULC Complex
Ribonucleoprotein Complex
Molecular Function
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
55 interactors:
ANKRD11
BEX2
CRACR2A
ENKD1
ERCC1
FAM110A
FAM124B
FARS2
KIF1A
LRSAM1
MDM2
MDM4
MEOX2
MNAT1
MRPS6
NABP1
NDE1
PEX10
PEX5
PRPF31
PSMA1
RBM41
RNF166
RNF32
RNF7
SCNM1
SF1
SFN
TCEA2
TCHP
TFAP2A
TRIM23
TRIM31
TRIM34
TRIM5
TRIM65
TRIM8
TSG101
TTC25
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L3
UBE2N
UBE2U
UBE2V1
UBE2V2
UBE2W
Entrez ID
148581
7681
HPRD ID
14599
04836
Ensembl ID
ENSG00000177414
ENSG00000179455
Uniprot IDs
Q5VVX9
Q13064
PDB IDs
1YRV
Enriched GO Terms of Interacting Partners
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Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Cellular Response To Stress
Catabolic Process
Cellular Response To DNA Damage Stimulus
Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Response To Stress
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Ubiquitin-protein Transferase Activity
Activation Of Innate Immune Response
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Proteolysis
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Cellular Response To Hypoxia
Positive Regulation Of Innate Immune Response
Cellular Response To Decreased Oxygen Levels
DNA Repair
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Innate Immune Response
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cell Cycle Process
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Protein Ubiquitination
Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Protein Catabolic Process
Viral Process
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