VPS11 and MSN

Number of citations of the paper that reports this interaction (PubMedID 21148287)
41

Data Source:
BioGRID (pull down)

		VPS11	MSN
Description		VPS11 core subunit of CORVET and HOPS complexes	moesin
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		SARS-CoV-2 modulates autophagy	Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)	Male-pattern baldness ( 28196072)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45	31 interacting genes: BCAP31 CD46 CD93 CDK11B CEBPA ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 NHERF1 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11
Entrez ID		55823	4478
HPRD ID		12258	02399
Ensembl ID		ENSG00000160695	ENSG00000147065
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	P26038 V9HWC0
PDB IDs			1E5W 1EF1 1SGH 6TXQ 6TXS 8CIR 8CIS 8CIT 8CIU
Enriched GO Terms of Interacting Partners?		Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process	Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Uropod Plasma Membrane Microvillus Membrane Docking Immune System Process Negative Regulation Of Signal Transduction Leukocyte Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Phagolysosome N-terminal Protein Myristoylation Regulation Of T Cell Proliferation Cell Activation Membrane Cell Migration Cell Periphery Positive Regulation Of Cell Adhesion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Plasma Membrane Raft Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Proliferation Activin Receptor Binding Protein Domain Specific Binding Protein Localization To Cell Periphery Leukocyte Migration Microvillus Assembly Negative Regulation Of Intracellular Signal Transduction Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Immunological Synapse Microvillus Organization Regulation Of Mononuclear Cell Proliferation Cell Motility Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Transport Regulation Of Leukocyte Proliferation Integrin Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Lymphocyte Activation
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