UBE2U and CGRRF1

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2U	CGRRF1
Gene Name		ubiquitin-conjugating enzyme E2U (putative)	cell growth regulator with ring finger domain 1
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Cytoplasm HULC Complex	Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Response To Stress Cell Cycle Arrest Negative Regulation Of Cell Proliferation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2	2 interactors: PEX10 UBE2U
Entrez ID		148581	10668
HPRD ID		14599	09366
Ensembl ID		ENSG00000177414	ENSG00000100532
Uniprot IDs		Q5VVX9	Q99675
PDB IDs		1YRV	2EA5
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction	Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Histone Ubiquitination Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Transmembrane Transport
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