VPS11 and TFAP2B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		VPS11	TFAP2B
Gene Name		vacuolar protein sorting 11 homolog (S. cerevisiae)	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Late Endosome Endocytic Vesicle HOPS Complex Late Endosome Membrane	Nucleus
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Syntaxin Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Renal Water Homeostasis Glucose Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Lithium Ion Retina Layer Formation Magnesium Ion Homeostasis Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Urine Volume Aorta Morphogenesis Response To Drug Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Regulation Of Insulin Secretion Phosphate Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure Cellular Ammonia Homeostasis Cellular Creatinine Homeostasis Cellular Urea Homeostasis
Pathways
Drugs
Diseases
GWAS			Adiposity ( 19557161) Body mass index ( 23563607 20935630) Metabolic syndrome (bivariate traits) ( 21386085) Obesity ( 23563607) Obesity (extreme) ( 21935397) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		25 interactors: BCAR1 BMI1 GGA3 KDM1A KIAA0368 KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45	11 interactors: CITED1 CITED2 CITED4 HIST1H2AC LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4
Entrez ID		55823	7021
HPRD ID		12258	03360
Ensembl ID		ENSG00000160695	ENSG00000008196
Uniprot IDs		Q9H270	Q92481
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Organization Vesicle Fusion Vesicle-mediated Transport Organelle Fusion Vesicle Docking Protein Transport Membrane Docking Establishment Of Protein Localization Membrane Fusion Vesicle Docking Involved In Exocytosis Protein Localization Viral Life Cycle Regulation Of Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Cellular Component Organization Intracellular Transport Establishment Of Localization In Cell Viral Entry Into Host Cell Organelle Organization Entry Into Host Cell Membrane Organization Regulation Of SNARE Complex Assembly Cellular Protein Localization Viral Budding Cellular Localization Endosomal Transport Interaction With Host Viral Process Transport Protein Ubiquitination Virion Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Exocytosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Endosome Organization Histone Ubiquitination Protein Polyubiquitination Regulation Of Vesicle Fusion Regulation Of Protein Localization Protein Autoubiquitination Regulation Of Vacuole Fusion, Non-autophagic Ubiquitin-dependent Endocytosis Positive Regulation Of Receptor Localization To Synapse Regulation Of Primitive Erythrocyte Differentiation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Organ Morphogenesis Response To Estrogen Positive Regulation Of Transcription, DNA-templated Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Response To Interleukin-11 Positive Regulation Of SUMO Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of Transcription, DNA-templated Kidney Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Cortex Formation Fibroblast Apoptotic Process Response To Steroid Hormone Axis Specification Regulation Of Gene Expression Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Mesonephros Development Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Interleukin-9 Transcription, DNA-templated Negative Regulation Of Gene Expression Nephron Development Negative Regulation Of Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia RNA Biosynthetic Process Kidney Epithelium Development Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Cellular Metabolic Process Determination Of Left/right Asymmetry In Lateral Mesoderm
Tagcloud ?			438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Difference) ?			438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Intersection) ?