UBE2U and RNF213

Number of citations of the paper that reports this interaction (PubMedID 33842849)
66

Data Source:
BioGRID (two hybrid)

		UBE2U	RNF213
Description		ubiquitin conjugating enzyme E2 U	ring finger protein 213
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GO Annotations	Cellular Component	HULC Complex	Nucleolus Cytoplasm Lipid Droplet Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding Catalytic Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Angiogenesis Sprouting Angiogenesis Immune System Process Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Protein Ubiquitination Regulation Of Lipid Metabolic Process Defense Response To Bacterium Protein Autoubiquitination Protein K63-linked Ubiquitination Xenophagy Lipid Ubiquitination Lipid Droplet Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Suppression of apoptosis Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 33020668) Hypertension ( 32709000) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Migraine ( 27182965 27322543) Moyamoya disease ( 21048783 29273593)
Interacting Genes		69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	17 interacting genes: GLUD1 GOLGA2 KRT40 MTDH PLAC9 REL SUMO2 TRIM23 TRIM27 TRIP6 UBC UBE2D2 UBE2D3 UBE2K UBE2L3 UBE2U UBXN11
Entrez ID		148581	57674
HPRD ID		14599	10716
Ensembl ID		ENSG00000177414	ENSG00000173821
Uniprot IDs		A0A0A0MRP4 A0A140VJY9 Q5VVX9	A0A0A0MTC1 A0A0A0MTR7 Q63HN8
PDB IDs		1YRV	8S24
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Macromolecule Catabolic Process Protein Tag Activity Proteolysis Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity SUMO Transferase Activity Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Catabolic Process Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Autophagy Macromolecule Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Sumoylation Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity ATP Binding Protein Autoubiquitination Transcription Coactivator Activity
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