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UBE2U and RNF139
Number of citations of the paper that reports this interaction (PMID
19690564
)
33
Data Source:
BioGRID
(two hybrid)
UBE2U
RNF139
Gene Name
ubiquitin-conjugating enzyme E2U (putative)
ring finger protein 139
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Cytoplasm
HULC Complex
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Molecular Function
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Protease Binding
Ubiquitin-protein Transferase Activity
Receptor Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cell Proliferation
Protein Ubiquitination
Negative Regulation Of Translation
Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Protein Processing
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
6 interactors:
COPS5
EIF3A
UBE2H
UBE2U
UBE2Z
VHL
Entrez ID
148581
11236
HPRD ID
14599
04333
Ensembl ID
ENSG00000177414
Uniprot IDs
Q5VVX9
Q8WU17
PDB IDs
1YRV
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Proteolysis
Cellular Protein Modification Process
Exosomal Secretion
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Formation Of Cytoplasmic Translation Initiation Complex
Translational Initiation
Mature Ribosome Assembly
Cullin Deneddylation
Ribosomal Subunit Export From Nucleus
Cytoplasmic Translational Initiation
Protein Deneddylation
Cytoplasmic Translation
Posttranscriptional Regulation Of Gene Expression
Formation Of Translation Preinitiation Complex
Protein K11-linked Ubiquitination
Ribosomal Large Subunit Biogenesis
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Modification-dependent Protein Catabolic Process
Ribosome Assembly
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Histone Ubiquitination
Protein Catabolic Process
Protein K48-linked Ubiquitination
Translation
Tagcloud
?
11q
16p
16q
17p
17q
18q
19q
2q
3q
4q
6p
8p
8q
9p
arrange
casp1
cdkn2d
cttn
fgf3
il12b
imbalances
macroscopically
mlpa
mme
mvp
nfkb1
ptk2
ptp4a3
tusc3
Tagcloud (Difference)
?
11q
16p
16q
17p
17q
18q
19q
2q
3q
4q
6p
8p
8q
9p
arrange
casp1
cdkn2d
cttn
fgf3
il12b
imbalances
macroscopically
mlpa
mme
mvp
nfkb1
ptk2
ptp4a3
tusc3
Tagcloud (Intersection)
?